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Linoleic acid–good or bad for the brain?
Increased intake of omega-6 rich plant oils such as soybean and corn oil over the past few decades has inadvertently tripled the amount of n-6 linoleic acid (LA, 18:2n-6) in the diet. Although LA is nutritionally “essential”, very little is known about how it affects the brain when present in excess...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940357/ https://www.ncbi.nlm.nih.gov/pubmed/31909187 http://dx.doi.org/10.1038/s41538-019-0061-9 |
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author | Taha, Ameer Y. |
author_facet | Taha, Ameer Y. |
author_sort | Taha, Ameer Y. |
collection | PubMed |
description | Increased intake of omega-6 rich plant oils such as soybean and corn oil over the past few decades has inadvertently tripled the amount of n-6 linoleic acid (LA, 18:2n-6) in the diet. Although LA is nutritionally “essential”, very little is known about how it affects the brain when present in excess. This review provides an overview on the metabolism of LA by the brain and the effects of excess dietary LA intake on brain function. Pre-clinical evidence suggests that excess dietary LA increases the brain’s vulnerability to inflammation and likely acts via its oxidized metabolites. In humans, excess maternal LA intake has been linked to atypical neurodevelopment, but underlying mechanisms are unknown. It is concluded that excess dietary LA may adversely affect the brain. The potential neuroprotective role of reducing dietary LA merits clinical evaluation in future studies. |
format | Online Article Text |
id | pubmed-6940357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69403572020-01-06 Linoleic acid–good or bad for the brain? Taha, Ameer Y. NPJ Sci Food Review Article Increased intake of omega-6 rich plant oils such as soybean and corn oil over the past few decades has inadvertently tripled the amount of n-6 linoleic acid (LA, 18:2n-6) in the diet. Although LA is nutritionally “essential”, very little is known about how it affects the brain when present in excess. This review provides an overview on the metabolism of LA by the brain and the effects of excess dietary LA intake on brain function. Pre-clinical evidence suggests that excess dietary LA increases the brain’s vulnerability to inflammation and likely acts via its oxidized metabolites. In humans, excess maternal LA intake has been linked to atypical neurodevelopment, but underlying mechanisms are unknown. It is concluded that excess dietary LA may adversely affect the brain. The potential neuroprotective role of reducing dietary LA merits clinical evaluation in future studies. Nature Publishing Group UK 2020-01-02 /pmc/articles/PMC6940357/ /pubmed/31909187 http://dx.doi.org/10.1038/s41538-019-0061-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Taha, Ameer Y. Linoleic acid–good or bad for the brain? |
title | Linoleic acid–good or bad for the brain? |
title_full | Linoleic acid–good or bad for the brain? |
title_fullStr | Linoleic acid–good or bad for the brain? |
title_full_unstemmed | Linoleic acid–good or bad for the brain? |
title_short | Linoleic acid–good or bad for the brain? |
title_sort | linoleic acid–good or bad for the brain? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940357/ https://www.ncbi.nlm.nih.gov/pubmed/31909187 http://dx.doi.org/10.1038/s41538-019-0061-9 |
work_keys_str_mv | AT tahaameery linoleicacidgoodorbadforthebrain |