Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption and associated illnesses, yet its aging mechanisms remain unclear. Here, we show that aging-caused intestinal villus structural and functional decline is regulated by mTORC1, a sensor of nutrients and gro...

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Detalles Bibliográficos
Autores principales: He, Dan, Wu, Hongguang, Xiang, Jinnan, Ruan, Xinsen, Peng, Peike, Ruan, Yuanyuan, Chen, Ye-Guang, Wang, Yibin, Yu, Qiang, Zhang, Hongbing, Habib, Samy L., De Pinho, Ronald A., Liu, Huijuan, Li, Baojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940394/
https://www.ncbi.nlm.nih.gov/pubmed/31896747
http://dx.doi.org/10.1038/s41467-019-13911-x

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