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Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity

OBJECTIVES: To investigate the tissue-protective effects of Ajwa date fruits (a Prophetic medicinal remedy) against acute diclofenac toxicity. METHODS: Albino Sprague–Dawley rats were allocated to four experimental groups: a negative control group, an Ajwa-only group that received 2 g/kg of Ajwa dat...

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Autores principales: Aljuhani, Naif, Elkablawy, Mohamed A., Elbadawy, Hossein M., Alahmadi, Abdulaziz M., Aloufi, Abdulrahman M., Farsi, Sultan H., Alhubayshi, Bashayr S., Alhejaili, Smaher S., Alhejaili, Jood M., Abdel-Halim, Osama B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taibah University 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940670/
https://www.ncbi.nlm.nih.gov/pubmed/31908644
http://dx.doi.org/10.1016/j.jtumed.2019.10.002
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author Aljuhani, Naif
Elkablawy, Mohamed A.
Elbadawy, Hossein M.
Alahmadi, Abdulaziz M.
Aloufi, Abdulrahman M.
Farsi, Sultan H.
Alhubayshi, Bashayr S.
Alhejaili, Smaher S.
Alhejaili, Jood M.
Abdel-Halim, Osama B.
author_facet Aljuhani, Naif
Elkablawy, Mohamed A.
Elbadawy, Hossein M.
Alahmadi, Abdulaziz M.
Aloufi, Abdulrahman M.
Farsi, Sultan H.
Alhubayshi, Bashayr S.
Alhejaili, Smaher S.
Alhejaili, Jood M.
Abdel-Halim, Osama B.
author_sort Aljuhani, Naif
collection PubMed
description OBJECTIVES: To investigate the tissue-protective effects of Ajwa date fruits (a Prophetic medicinal remedy) against acute diclofenac toxicity. METHODS: Albino Sprague–Dawley rats were allocated to four experimental groups: a negative control group, an Ajwa-only group that received 2 g/kg of Ajwa date extract (ADE) orally, an acute diclofenac toxicity group that received 200 mg diclofenac once intraperitoneally, and a treatment group that received diclofenac and ADE after 4 h. Histological examinations of rat lung and liver tissues were performed. RESULTS: Acute diclofenac toxicity caused marked hepatic derangements, such as congested central veins, congested blood sinusoids, hyaline degeneration, and hepatocyte necrosis. Toxic diclofenac overdose resulted in markedly congested alveolar capillaries and alveolar haemorrhages, thick edematous alveolar walls, and edema fluid exudates in the alveoli. Upon treatment with ADE, significant reduction in diclofenac-induced hepatic and pulmonary derangements were observed. CONCLUSION: ADE is a safe, tissue-protective nutritional agent that alleviates cellular and tissue-damaging effects due to acute diclofenac toxicity. ADE relieved hepatic and pulmonary changes induced by acute diclofenac toxicity. The use of ADE is recommended for the treatment of acute diclofenac toxicity.
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spelling pubmed-69406702020-01-06 Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity Aljuhani, Naif Elkablawy, Mohamed A. Elbadawy, Hossein M. Alahmadi, Abdulaziz M. Aloufi, Abdulrahman M. Farsi, Sultan H. Alhubayshi, Bashayr S. Alhejaili, Smaher S. Alhejaili, Jood M. Abdel-Halim, Osama B. J Taibah Univ Med Sci Original Article OBJECTIVES: To investigate the tissue-protective effects of Ajwa date fruits (a Prophetic medicinal remedy) against acute diclofenac toxicity. METHODS: Albino Sprague–Dawley rats were allocated to four experimental groups: a negative control group, an Ajwa-only group that received 2 g/kg of Ajwa date extract (ADE) orally, an acute diclofenac toxicity group that received 200 mg diclofenac once intraperitoneally, and a treatment group that received diclofenac and ADE after 4 h. Histological examinations of rat lung and liver tissues were performed. RESULTS: Acute diclofenac toxicity caused marked hepatic derangements, such as congested central veins, congested blood sinusoids, hyaline degeneration, and hepatocyte necrosis. Toxic diclofenac overdose resulted in markedly congested alveolar capillaries and alveolar haemorrhages, thick edematous alveolar walls, and edema fluid exudates in the alveoli. Upon treatment with ADE, significant reduction in diclofenac-induced hepatic and pulmonary derangements were observed. CONCLUSION: ADE is a safe, tissue-protective nutritional agent that alleviates cellular and tissue-damaging effects due to acute diclofenac toxicity. ADE relieved hepatic and pulmonary changes induced by acute diclofenac toxicity. The use of ADE is recommended for the treatment of acute diclofenac toxicity. Taibah University 2019-11-27 /pmc/articles/PMC6940670/ /pubmed/31908644 http://dx.doi.org/10.1016/j.jtumed.2019.10.002 Text en © 2019 Taibah University. Production and hosting by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Aljuhani, Naif
Elkablawy, Mohamed A.
Elbadawy, Hossein M.
Alahmadi, Abdulaziz M.
Aloufi, Abdulrahman M.
Farsi, Sultan H.
Alhubayshi, Bashayr S.
Alhejaili, Smaher S.
Alhejaili, Jood M.
Abdel-Halim, Osama B.
Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity
title Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity
title_full Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity
title_fullStr Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity
title_full_unstemmed Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity
title_short Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity
title_sort protective effects of ajwa date extract against tissue damage induced by acute diclofenac toxicity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940670/
https://www.ncbi.nlm.nih.gov/pubmed/31908644
http://dx.doi.org/10.1016/j.jtumed.2019.10.002
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