HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy

A 30-year-old man with advanced HIV and disseminated histoplasmosis deteriorated after stepping down from intravenous liposomal amphotericin B to itraconazole. Therapeutic levels of itraconazole and posaconazole were not achieved, therefore liposomal amphotericin B was reintroduced. Stepdown treatme...

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Detalles Bibliográficos
Autores principales: Mazzella, Andrea, Stone, Neil R.H., Pool, Erica R.M., García Mingo, Ana, Bolache, Sorina, Wood, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940692/
https://www.ncbi.nlm.nih.gov/pubmed/31908913
http://dx.doi.org/10.1016/j.mmcr.2019.12.013
Descripción
Sumario:A 30-year-old man with advanced HIV and disseminated histoplasmosis deteriorated after stepping down from intravenous liposomal amphotericin B to itraconazole. Therapeutic levels of itraconazole and posaconazole were not achieved, therefore liposomal amphotericin B was reintroduced. Stepdown treatment was switched to oral isavuconazole; since then the patient has remained well.

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