HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy

A 30-year-old man with advanced HIV and disseminated histoplasmosis deteriorated after stepping down from intravenous liposomal amphotericin B to itraconazole. Therapeutic levels of itraconazole and posaconazole were not achieved, therefore liposomal amphotericin B was reintroduced. Stepdown treatme...

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Detalles Bibliográficos
Autores principales: Mazzella, Andrea, Stone, Neil R.H., Pool, Erica R.M., García Mingo, Ana, Bolache, Sorina, Wood, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940692/
https://www.ncbi.nlm.nih.gov/pubmed/31908913
http://dx.doi.org/10.1016/j.mmcr.2019.12.013
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author Mazzella, Andrea
Stone, Neil R.H.
Pool, Erica R.M.
García Mingo, Ana
Bolache, Sorina
Wood, Chris
author_facet Mazzella, Andrea
Stone, Neil R.H.
Pool, Erica R.M.
García Mingo, Ana
Bolache, Sorina
Wood, Chris
author_sort Mazzella, Andrea
collection PubMed
description A 30-year-old man with advanced HIV and disseminated histoplasmosis deteriorated after stepping down from intravenous liposomal amphotericin B to itraconazole. Therapeutic levels of itraconazole and posaconazole were not achieved, therefore liposomal amphotericin B was reintroduced. Stepdown treatment was switched to oral isavuconazole; since then the patient has remained well.
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spelling pubmed-69406922020-01-06 HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy Mazzella, Andrea Stone, Neil R.H. Pool, Erica R.M. García Mingo, Ana Bolache, Sorina Wood, Chris Med Mycol Case Rep Case Report A 30-year-old man with advanced HIV and disseminated histoplasmosis deteriorated after stepping down from intravenous liposomal amphotericin B to itraconazole. Therapeutic levels of itraconazole and posaconazole were not achieved, therefore liposomal amphotericin B was reintroduced. Stepdown treatment was switched to oral isavuconazole; since then the patient has remained well. Elsevier 2019-12-20 /pmc/articles/PMC6940692/ /pubmed/31908913 http://dx.doi.org/10.1016/j.mmcr.2019.12.013 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Mazzella, Andrea
Stone, Neil R.H.
Pool, Erica R.M.
García Mingo, Ana
Bolache, Sorina
Wood, Chris
HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title_full HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title_fullStr HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title_full_unstemmed HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title_short HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title_sort hiv-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940692/
https://www.ncbi.nlm.nih.gov/pubmed/31908913
http://dx.doi.org/10.1016/j.mmcr.2019.12.013
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