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Data of detection and characterization of nitrated conjugated-linoleic acid (NO(2)-cLA) in LDL

Under physiological and pathophysiological conditions, lipid nitration occurs generating nitro-fatty acids (NFA) with pleiotropic activities as modulation of inflammatory cell responses. Foam cell formation and atherosclerotic lesion development have been extensively related to low-density lipoprote...

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Detalles Bibliográficos
Autores principales: Mastrogiovanni, Mauricio, Trostchansky, Andres, Rubbo, Homero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940714/
https://www.ncbi.nlm.nih.gov/pubmed/31909129
http://dx.doi.org/10.1016/j.dib.2019.105037
Descripción
Sumario:Under physiological and pathophysiological conditions, lipid nitration occurs generating nitro-fatty acids (NFA) with pleiotropic activities as modulation of inflammatory cell responses. Foam cell formation and atherosclerotic lesion development have been extensively related to low-density lipoprotein (LDL) oxidation. Considering our manuscript “Fatty acid nitration in human low-density lipoprotein” (https://doi.org/10.1016/j.abb.2019.108190), herein we report the oxidation versus nitration of human LDL protein and lipid fractions. Data is shown on LDL fatty acid nitration, in particular, formation and quantitation of nitro-conjugated linoleic acid (NO(2)-cLA) under mild nitration conditions. In parallel to NO(2)-cLA formation, depletion of endogenous antioxidants, protein tyrosine nitration, and carbonyl formation is observed. Overall, our data propose the formation of a potential anti-atherogenic form of LDL carrying NFA.