Cargando…

LDHA Suppression Altering Metabolism Inhibits Tumor Progress by an Organic Arsenical

Based on the potential therapeutic value in targeting metabolism for the treatment of cancer, an organic arsenical PDT-BIPA was fabricated, which exerted selective anti-cancer activity in vitro and in vivo via targeting lactate dehydrogenase A (LDHA) to remodel the metabolic pathway. In details, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yu-Jiao, Fan, Xiao-Yang, Wang, An-Dong, Xia, Yin-Zheng, Fu, Wen-Rong, Liu, Jun-Yi, Jiang, Feng-Lei, Liu, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940739/ https://www.ncbi.nlm.nih.gov/pubmed/31835667 http://dx.doi.org/10.3390/ijms20246239

Ejemplares similares

Inhibition of LDHA suppresses tumor progression in prostate cancer
por: Xian, Zhi-Yong, et al.
Publicado: (2015)

Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma
por: Li, Sen, et al.
Publicado: (2019)

Starvation induced autophagy promotes the progression of bladder cancer by LDHA mediated metabolic reprogramming
por: Li, Tinghao, et al.
Publicado: (2021)

Inhibition of KDM4C/c‐Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism
por: Lin, Ching‐Yu, et al.
Publicado: (2022)

BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer
por: Niu, Weihong, et al.
Publicado: (2018)

Retraction Note: BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer
por: Niu, Weihong, et al.
Publicado: (2019)

LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression
por: Khan, Fatima, et al.
Publicado: (2023)

Novel Peptide Inhibitors for Lactate Dehydrogenase A (LDHA): A Survey to Inhibit LDHA Activity via Disruption of Protein-Protein Interaction
por: Jafary, Farzaneh, et al.
Publicado: (2019)

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA
por: Thongon, Natthakan, et al.
Publicado: (2018)

PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA
por: Shi, Liang, et al.
Publicado: (2020)

JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer*
por: Qiu, Haifeng, et al.
Publicado: (2015)

JMJD2A promotes the Warburg effect and nasopharyngeal carcinoma progression by transactivating LDHA expression
por: Su, Yi, et al.
Publicado: (2017)

The c-Myc–LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer
por: He, Tian-Lin, et al.
Publicado: (2015)

PGC1β regulates multiple myeloma tumor growth through LDHA‐mediated glycolytic metabolism
por: Zhang, Hongyu, et al.
Publicado: (2018)

USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis
por: Liu, Shuguang, et al.
Publicado: (2023)

Inhibition of LDHA suppresses cell proliferation and increases mitochondrial apoptosis via the JNK signaling pathway in cervical cancer cells
por: Zhang, Wenjing, et al.
Publicado: (2022)

Oxidative stress-mediated intrinsic apoptosis in human promyelocytic leukemia HL-60 cells induced by organic arsenicals
por: Fan, Xiao-Yang, et al.
Publicado: (2016)

Transcriptional, chromatin, and metabolic landscapes of LDHA inhibitor–resistant pancreatic ductal adenocarcinoma
por: Malvi, Parmanand, et al.
Publicado: (2022)

Ldha-Dependent Metabolic Programs in Sertoli Cells Regulate Spermiogenesis in Mouse Testis
por: Zhang, Xiao-Na, et al.
Publicado: (2022)

Effect of LDHA Inhibition on TNF-α-Induced Cell Migration in Esophageal Cancers
por: Forkasiewicz, Agata, et al.
Publicado: (2022)

POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation
por: Martínez-Ordoñez, Anxo, et al.
Publicado: (2021)

LDHA: The Obstacle to T cell responses against tumor
por: Tang, Yu, et al.
Publicado: (2022)

Arginine is neuroprotective through suppressing HIF-1α/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury
por: Chen, Song-Feng, et al.
Publicado: (2020)

Hypoxia‐induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression
por: Wang, Xiao‐Hong, et al.
Publicado: (2021)

Synergistic cytotoxicity of cisplatin and Taxol in overcoming Taxol resistance through the inhibition of LDHA in oral squamous cell carcinoma
por: FENG, LIN, et al.
Publicado: (2015)

CENPE and LDHA were potential prognostic biomarkers of chromophobe renal cell carcinoma
por: Wu, Hui-feng, et al.
Publicado: (2023)

miR-449a Suppresses LDHA-Mediated Glycolysis to Enhance the Sensitivity of Non-Small Cell Lung Cancer Cells to Ionizing Radiation
por: Li, Liang, et al.
Publicado: (2018)

Long Non-Coding RNA DUXAP8 Facilitates Cell Viability, Migration, and Glycolysis in Non-Small-Cell Lung Cancer via Regulating HK2 and LDHA by Inhibition of miR-409-3p
por: Yin, Dianhe, et al.
Publicado: (2020)

LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization
por: Chen, Yijin, et al.
Publicado: (2022)

Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia
por: Yu, Haizhi, et al.
Publicado: (2020)

FAM46B Promotes Apoptosis and Inhibits Glycolysis of Prostate Cancer Through Inhibition of the MYC-LDHA Axis
por: Liang, Tao, et al.
Publicado: (2020)

LDHA Promotes Oral Squamous Cell Carcinoma Progression Through Facilitating Glycolysis and Epithelial–Mesenchymal Transition
por: Cai, Hongshi, et al.
Publicado: (2019)

Arsenic-induced Histological Alterations in Various Organs of Mice
por: Noman, Abu Shadat Mohammod, et al.
Publicado: (2015)

LDHA gene is associated with pigeon survivability during racing competitions
por: Ramadan, Sherif, et al.
Publicado: (2018)

The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer
por: Xiao, Xiangsheng, et al.
Publicado: (2016)

KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma
por: Jiang, Yuhang, et al.
Publicado: (2021)

Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway
por: Fu, Xiaomei, et al.
Publicado: (2021)

Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer
por: Wang, Haohua, et al.
Publicado: (2018)

Combined Aberrant Expression of NDRG2 and LDHA Predicts Hepatocellular Carcinoma Prognosis and Mediates the Anti-tumor Effect of Gemcitabine
por: Guo, Yan, et al.
Publicado: (2019)

Urinary Creatinine and Arsenic Metabolism
por: Gamble, Mary V., et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_i4kp48jftfve61iq9m0dciq3qd