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Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis
The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent, novel oncogenic functions, a phenomenon termed mutant p53 gain-of-function (GOF). A growing body of evidence suggests that th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940767/ https://www.ncbi.nlm.nih.gov/pubmed/31817996 http://dx.doi.org/10.3390/ijms20246197 |