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The Distribution Characteristics of a 19-bp Indel of the PLAG1 Gene in Chinese Cattle

SIMPLE SUMMARY: Growth traits are important quantitative traits for cattle performance, which influences herd productivity. Previous studies demonstrated that a 19-bp indel in pleomorphic adenoma gene 1 (PLAG1) is associated with bovine growth traits. In our studies, the distribution of the 19-bp in...

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Autores principales: Zhou, Zihui, Huang, Bizhi, Lai, Zhenyu, Li, Shipeng, Wu, Fei, Qu, Kaixing, Jia, Yutang, Hou, Jiawen, Liu, Jianyong, Lei, Chuzhao, Dang, Ruihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940828/
https://www.ncbi.nlm.nih.gov/pubmed/31817264
http://dx.doi.org/10.3390/ani9121082
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author Zhou, Zihui
Huang, Bizhi
Lai, Zhenyu
Li, Shipeng
Wu, Fei
Qu, Kaixing
Jia, Yutang
Hou, Jiawen
Liu, Jianyong
Lei, Chuzhao
Dang, Ruihua
author_facet Zhou, Zihui
Huang, Bizhi
Lai, Zhenyu
Li, Shipeng
Wu, Fei
Qu, Kaixing
Jia, Yutang
Hou, Jiawen
Liu, Jianyong
Lei, Chuzhao
Dang, Ruihua
author_sort Zhou, Zihui
collection PubMed
description SIMPLE SUMMARY: Growth traits are important quantitative traits for cattle performance, which influences herd productivity. Previous studies demonstrated that a 19-bp indel in pleomorphic adenoma gene 1 (PLAG1) is associated with bovine growth traits. In our studies, the distribution of the 19-bp indel of PLAG1 gene among 37 Chinese cattle breeds and the association between this indel and growth traits of Yunling cattle were explored. As a result, we found that the average body height of various Chinese cattle breeds showed an increasing trend from south to north of China, which was consistent with the distribution trend of the 19-bp indel in cattle at different geographic latitudes. Moreover, this indel was verified to be significantly associated with the growth traits of Yunling cattle. Our results showed that the 19-bp indel in PLAG1 strongly influences body size in Chinese cattle. ABSTRACT: Pleomorphic adenoma gene 1 (PLAG1) belongs to the PLAG family of zinc finger transcription factors. In cattle, a 19-bp insertion/deletion (indel) was identified in intron 1 of the PLAG1 gene (GenBank Accession No. AC_000171.1). Researches showed that the indel is polymorphic in Chinese cattle breeds such as Qinchuan cattle, Pinan cattle, Xianan cattle, and Jiaxian red cattle, and correlation analysis showed that the polymorphism is related to the height of these cattle breeds. Chinese cattle breeds show a difference in height related to geographical distribution. We investigated the distribution of the 19-bp indel polymorphism in 37 cattle breeds, including 1354 individuals. The results showed that there were three genotypes and two alleles (W, 366 bp; D, 347 bp). From northern cattle to southern cattle, the frequency of W allele gradually decreased, while the frequency of D allele showed an opposite trend, which was consistent with the distribution of cattle breeds of different height in China. Therefore, the polymorphism of this indel may be related to the regional distribution of cattle breeds in China. In addition, we chose Yunling cattle with a mixed genetic background to study the genetic effects of the 19-bp indel on body size traits. Statistical analysis showed that PLAG1 was significantly associated with the body height, cross height, and chest circumference of Yunling cattle (p < 0.05). This study provides new evidence that the 19-bp indel of the PLAG1 gene is a highly effective trait marker that can be used as a candidate molecular marker for cattle breeding.
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spelling pubmed-69408282020-01-09 The Distribution Characteristics of a 19-bp Indel of the PLAG1 Gene in Chinese Cattle Zhou, Zihui Huang, Bizhi Lai, Zhenyu Li, Shipeng Wu, Fei Qu, Kaixing Jia, Yutang Hou, Jiawen Liu, Jianyong Lei, Chuzhao Dang, Ruihua Animals (Basel) Article SIMPLE SUMMARY: Growth traits are important quantitative traits for cattle performance, which influences herd productivity. Previous studies demonstrated that a 19-bp indel in pleomorphic adenoma gene 1 (PLAG1) is associated with bovine growth traits. In our studies, the distribution of the 19-bp indel of PLAG1 gene among 37 Chinese cattle breeds and the association between this indel and growth traits of Yunling cattle were explored. As a result, we found that the average body height of various Chinese cattle breeds showed an increasing trend from south to north of China, which was consistent with the distribution trend of the 19-bp indel in cattle at different geographic latitudes. Moreover, this indel was verified to be significantly associated with the growth traits of Yunling cattle. Our results showed that the 19-bp indel in PLAG1 strongly influences body size in Chinese cattle. ABSTRACT: Pleomorphic adenoma gene 1 (PLAG1) belongs to the PLAG family of zinc finger transcription factors. In cattle, a 19-bp insertion/deletion (indel) was identified in intron 1 of the PLAG1 gene (GenBank Accession No. AC_000171.1). Researches showed that the indel is polymorphic in Chinese cattle breeds such as Qinchuan cattle, Pinan cattle, Xianan cattle, and Jiaxian red cattle, and correlation analysis showed that the polymorphism is related to the height of these cattle breeds. Chinese cattle breeds show a difference in height related to geographical distribution. We investigated the distribution of the 19-bp indel polymorphism in 37 cattle breeds, including 1354 individuals. The results showed that there were three genotypes and two alleles (W, 366 bp; D, 347 bp). From northern cattle to southern cattle, the frequency of W allele gradually decreased, while the frequency of D allele showed an opposite trend, which was consistent with the distribution of cattle breeds of different height in China. Therefore, the polymorphism of this indel may be related to the regional distribution of cattle breeds in China. In addition, we chose Yunling cattle with a mixed genetic background to study the genetic effects of the 19-bp indel on body size traits. Statistical analysis showed that PLAG1 was significantly associated with the body height, cross height, and chest circumference of Yunling cattle (p < 0.05). This study provides new evidence that the 19-bp indel of the PLAG1 gene is a highly effective trait marker that can be used as a candidate molecular marker for cattle breeding. MDPI 2019-12-04 /pmc/articles/PMC6940828/ /pubmed/31817264 http://dx.doi.org/10.3390/ani9121082 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Zihui
Huang, Bizhi
Lai, Zhenyu
Li, Shipeng
Wu, Fei
Qu, Kaixing
Jia, Yutang
Hou, Jiawen
Liu, Jianyong
Lei, Chuzhao
Dang, Ruihua
The Distribution Characteristics of a 19-bp Indel of the PLAG1 Gene in Chinese Cattle
title The Distribution Characteristics of a 19-bp Indel of the PLAG1 Gene in Chinese Cattle
title_full The Distribution Characteristics of a 19-bp Indel of the PLAG1 Gene in Chinese Cattle
title_fullStr The Distribution Characteristics of a 19-bp Indel of the PLAG1 Gene in Chinese Cattle
title_full_unstemmed The Distribution Characteristics of a 19-bp Indel of the PLAG1 Gene in Chinese Cattle
title_short The Distribution Characteristics of a 19-bp Indel of the PLAG1 Gene in Chinese Cattle
title_sort distribution characteristics of a 19-bp indel of the plag1 gene in chinese cattle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940828/
https://www.ncbi.nlm.nih.gov/pubmed/31817264
http://dx.doi.org/10.3390/ani9121082
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