Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype

The kinase AKT2 (PKB) is an important mediator of insulin signaling, for which loss-of-function knockout (KO) mutants lead to early onset diabetes mellitus, and dominant active mutations lead to early development of obesity and endothelial cell (EC) dysfunction. To model EC dysfunction, we used edit...

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Detalles Bibliográficos
Autores principales: Roudnicky, Filip, Lan, Yanjun, Friesen, Max, Dernick, Gregor, Zhang, Jitao David, Staempfli, Andreas, Bordag, Natalie, Wagner-Golbs, Antje, Christensen, Klaus, Ebeling, Martin, Graf, Martin, Burcin, Mark, Meyer, Claas Aiko, Cowan, Chad A, Patsch, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940871/
https://www.ncbi.nlm.nih.gov/pubmed/31835296
http://dx.doi.org/10.3390/ijms20246201

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