Cargando…

Novel Drug-Like Somatostatin Receptor 4 Agonists are Potential Analgesics for Neuropathic Pain

Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via the somatostatin sst(4) receptor without endocrine actions. Therefore, sst(4) is considered to be a novel target for drug development in pain including chronic neuropathy, which is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kántás, Boglárka, Börzsei, Rita, Szőke, Éva, Bánhegyi, Péter, Horváth, Ádám, Hunyady, Ágnes, Borbély, Éva, Hetényi, Csaba, Pintér, Erika, Helyes, Zsuzsanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940912/ https://www.ncbi.nlm.nih.gov/pubmed/31835716 http://dx.doi.org/10.3390/ijms20246245

Ejemplares similares

In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST(4) Receptor Agonists
por: Kántás, Boglárka, et al.
Publicado: (2021)

Exploration of Somatostatin Binding Mechanism to Somatostatin Receptor Subtype 4
por: Börzsei, Rita, et al.
Publicado: (2022)

Antinociceptive Effects of Lipid Raft Disruptors, a Novel Carboxamido-Steroid and Methyl β-Cyclodextrin, in Mice by Inhibiting Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Channel Activation
por: Horváth, Ádám, et al.
Publicado: (2020)

Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation
por: Horváth, Ádám, et al.
Publicado: (2021)

Prerequisite Binding Modes Determine the Dynamics of Action of Covalent Agonists of Ion Channel TRPA1
por: Zsidó, Balázs Zoltán, et al.
Publicado: (2021)

Hemokinin-1 as a Mediator of Arthritis-Related Pain via Direct Activation of Primary Sensory Neurons
por: Borbély, Éva, et al.
Publicado: (2021)

Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains
por: Kecskés, Angéla, et al.
Publicado: (2020)

Role of Transient Receptor Potential Ankyrin 1 Ion Channel and Somatostatin sst4 Receptor in the Antinociceptive and Anti-inflammatory Effects of Sodium Polysulfide and Dimethyl Trisulfide
por: Bátai, István Z., et al.
Publicado: (2018)

Exploratory and locomotor activity, learning and memory functions in somatostatin receptor subtype 4 gene-deficient mice in relation to aging and sex
por: Szentes, Nikolett, et al.
Publicado: (2019)

Important regulatory function of transient receptor potential ankyrin 1 receptors in age-related learning and memory alterations of mice
por: Borbély, Éva, et al.
Publicado: (2019)

Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse
por: Horváth, Ádám, et al.
Publicado: (2017)

Somatostatin Primes Endothelial Cells for Agonist-Induced Hyperpermeability and Angiogenesis In Vitro
por: Aslam, Muhammad, et al.
Publicado: (2022)

Plasma Somatostatin Levels Increase during Scoliosis Surgery, but Not Herniated Disc Operations: Results of a Pilot Study
por: Sütő, Balázs, et al.
Publicado: (2023)

Molecular Links between Sensory Nerves, Inflammation, and Pain 2.0
por: Szőke, Éva, et al.
Publicado: (2023)

IL-1 Mediates Chronic Stress-Induced Hyperalgesia Accompanied by Microglia and Astroglia Morphological Changes in Pain-Related Brain Regions in Mice
por: Fülöp, Barbara, et al.
Publicado: (2023)

Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice
por: Horváth, Ádám, et al.
Publicado: (2016)

Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain
por: Horváth, Ádám István, et al.
Publicado: (2021)

Complex Role of Capsaicin-Sensitive Afferents in the Collagen Antibody-Induced Autoimmune Arthritis of the Mouse
por: Borbély, Éva, et al.
Publicado: (2018)

A Novel G Protein–Biased Agonist at the δ Opioid Receptor with Analgesic Efficacy in Models of Chronic Pain
por: Conibear, Alexandra E., et al.
Publicado: (2020)

Human Somatostatin SST(4) Receptor Transgenic Mice: Construction and Brain Expression Pattern Characterization
por: Nemes, Balázs, et al.
Publicado: (2021)

Determination of Ligand Binding Modes in Hydrated Viral Ion Channels to Foster Drug Design and Repositioning
por: Zsidó, Balázs Zoltán, et al.
Publicado: (2021)

Construction of Histone–Protein Complex Structures by Peptide Growing
por: Zsidó, Balázs Zoltán, et al.
Publicado: (2023)

Investigation of the Role of the TRPA1 Ion Channel in Conveying the Effect of Dimethyl Trisulfide on Vascular and Histological Changes in Serum-Transfer Arthritis
por: Bátai, István Z., et al.
Publicado: (2022)

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis
por: Bátai, István Z., et al.
Publicado: (2019)

Capsaicin-sensitive sensory nerves, TRPV1 receptors and tachykinins play important roles in mast cell tryptase-induced arthritis and hyperalgesia
por: Helyes, Zsuzsanna, et al.
Publicado: (2011)

The Structural Effects of Phosphorylation of Protein Arginine Methyltransferase 5 on Its Binding to Histone H4
por: Börzsei, Rita, et al.
Publicado: (2022)

Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor
por: Nemes, Balázs, et al.
Publicado: (2023)

Hemokinin-1 induces transcriptomic alterations in pain-related signaling processes in rat primary sensory neurons independent of NK1 tachykinin receptor activation
por: Takács-Lovász, Krisztina, et al.
Publicado: (2023)

The Advances and Limitations of the Determination and Applications of Water Structure in Molecular Engineering
por: Zsidó, Balázs Zoltán, et al.
Publicado: (2023)

Editorial: Targeting Neuro-Immuno-Vascular Interactions in the Brain and the Periphery
por: Wilhelm, Imola, et al.
Publicado: (2022)

Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis
por: Borbély, Éva, et al.
Publicado: (2015)

Somatostatin and Its Receptors in Myocardial Ischemia/Reperfusion Injury and Cardioprotection
por: Vörös, Imre, et al.
Publicado: (2021)

Carboxamido steroids inhibit the opening properties of transient receptor potential ion channels by lipid raft modulation
por: Sághy, Éva, et al.
Publicado: (2018)

Novel drug developmental strategies for treatment‐resistant depression
por: Borbély, Éva, et al.
Publicado: (2022)

Desensitization of Capsaicin-Sensitive Afferents Accelerates Early Tumor Growth via Increased Vascular Leakage in a Murine Model of Triple Negative Breast Cancer
por: Bencze, Noémi, et al.
Publicado: (2021)

Role of Tachykinin 1 and 4 Gene-Derived Neuropeptides and the Neurokinin 1 Receptor in Adjuvant-Induced Chronic Arthritis of the Mouse
por: Borbély, Éva, et al.
Publicado: (2013)

Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice
por: Czárán, Domonkos, et al.
Publicado: (2023)

Resolvin D1 and D2 Inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel Activation on Sensory Neurons via Lipid Raft Modification
por: Payrits, Maja, et al.
Publicado: (2020)

Analyzing the Carotenoid Composition of Melilot (Melilotus officinalis (L.) Pall.) Extracts and the Effects of Isolated (All-E)-lutein-5,6-epoxide on Primary Sensory Neurons and Macrophages
por: Horváth, Györgyi, et al.
Publicado: (2021)

Transcriptional Alterations in the Trigeminal Ganglia, Nucleus and Peripheral Blood Mononuclear Cells in a Rat Orofacial Pain Model
por: Aczél, Timea, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_74vsumracso1r53tajfpb0lpc5