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High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives

Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The complications of diabetes can affect potentially all parts of the human body, from the heart to the kidneys, peripheral and central nervous system, and the vascular bed. Although many mechanisms have been studied...

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Autores principales: Biscetti, Federico, Rando, Maria Margherita, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Pecorini, Giovanni, Landolfi, Raffaele, Flex, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940913/
https://www.ncbi.nlm.nih.gov/pubmed/31835864
http://dx.doi.org/10.3390/ijms20246258
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author Biscetti, Federico
Rando, Maria Margherita
Nardella, Elisabetta
Cecchini, Andrea Leonardo
Pecorini, Giovanni
Landolfi, Raffaele
Flex, Andrea
author_facet Biscetti, Federico
Rando, Maria Margherita
Nardella, Elisabetta
Cecchini, Andrea Leonardo
Pecorini, Giovanni
Landolfi, Raffaele
Flex, Andrea
author_sort Biscetti, Federico
collection PubMed
description Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The complications of diabetes can affect potentially all parts of the human body, from the heart to the kidneys, peripheral and central nervous system, and the vascular bed. Although many mechanisms have been studied, not all players responsible for these complications have been defined yet. High Mobility Group Box-1 (HMGB1) is a non-histone nuclear protein that has been implicated in many pathological processes, from sepsis to ischemia. The purpose of this review is to take stock of all the most recent data available on the role of HMGB1 in the complications of DM.
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spelling pubmed-69409132020-01-09 High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives Biscetti, Federico Rando, Maria Margherita Nardella, Elisabetta Cecchini, Andrea Leonardo Pecorini, Giovanni Landolfi, Raffaele Flex, Andrea Int J Mol Sci Review Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The complications of diabetes can affect potentially all parts of the human body, from the heart to the kidneys, peripheral and central nervous system, and the vascular bed. Although many mechanisms have been studied, not all players responsible for these complications have been defined yet. High Mobility Group Box-1 (HMGB1) is a non-histone nuclear protein that has been implicated in many pathological processes, from sepsis to ischemia. The purpose of this review is to take stock of all the most recent data available on the role of HMGB1 in the complications of DM. MDPI 2019-12-11 /pmc/articles/PMC6940913/ /pubmed/31835864 http://dx.doi.org/10.3390/ijms20246258 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Biscetti, Federico
Rando, Maria Margherita
Nardella, Elisabetta
Cecchini, Andrea Leonardo
Pecorini, Giovanni
Landolfi, Raffaele
Flex, Andrea
High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
title High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
title_full High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
title_fullStr High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
title_full_unstemmed High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
title_short High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
title_sort high mobility group box-1 and diabetes mellitus complications: state of the art and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940913/
https://www.ncbi.nlm.nih.gov/pubmed/31835864
http://dx.doi.org/10.3390/ijms20246258
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