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High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The complications of diabetes can affect potentially all parts of the human body, from the heart to the kidneys, peripheral and central nervous system, and the vascular bed. Although many mechanisms have been studied...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940913/ https://www.ncbi.nlm.nih.gov/pubmed/31835864 http://dx.doi.org/10.3390/ijms20246258 |
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author | Biscetti, Federico Rando, Maria Margherita Nardella, Elisabetta Cecchini, Andrea Leonardo Pecorini, Giovanni Landolfi, Raffaele Flex, Andrea |
author_facet | Biscetti, Federico Rando, Maria Margherita Nardella, Elisabetta Cecchini, Andrea Leonardo Pecorini, Giovanni Landolfi, Raffaele Flex, Andrea |
author_sort | Biscetti, Federico |
collection | PubMed |
description | Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The complications of diabetes can affect potentially all parts of the human body, from the heart to the kidneys, peripheral and central nervous system, and the vascular bed. Although many mechanisms have been studied, not all players responsible for these complications have been defined yet. High Mobility Group Box-1 (HMGB1) is a non-histone nuclear protein that has been implicated in many pathological processes, from sepsis to ischemia. The purpose of this review is to take stock of all the most recent data available on the role of HMGB1 in the complications of DM. |
format | Online Article Text |
id | pubmed-6940913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69409132020-01-09 High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives Biscetti, Federico Rando, Maria Margherita Nardella, Elisabetta Cecchini, Andrea Leonardo Pecorini, Giovanni Landolfi, Raffaele Flex, Andrea Int J Mol Sci Review Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The complications of diabetes can affect potentially all parts of the human body, from the heart to the kidneys, peripheral and central nervous system, and the vascular bed. Although many mechanisms have been studied, not all players responsible for these complications have been defined yet. High Mobility Group Box-1 (HMGB1) is a non-histone nuclear protein that has been implicated in many pathological processes, from sepsis to ischemia. The purpose of this review is to take stock of all the most recent data available on the role of HMGB1 in the complications of DM. MDPI 2019-12-11 /pmc/articles/PMC6940913/ /pubmed/31835864 http://dx.doi.org/10.3390/ijms20246258 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Biscetti, Federico Rando, Maria Margherita Nardella, Elisabetta Cecchini, Andrea Leonardo Pecorini, Giovanni Landolfi, Raffaele Flex, Andrea High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives |
title | High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives |
title_full | High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives |
title_fullStr | High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives |
title_full_unstemmed | High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives |
title_short | High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives |
title_sort | high mobility group box-1 and diabetes mellitus complications: state of the art and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940913/ https://www.ncbi.nlm.nih.gov/pubmed/31835864 http://dx.doi.org/10.3390/ijms20246258 |
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