Cargando…

Natural Flavonol, Myricetin, Enhances the Function and Survival of Cryopreserved Hepatocytes In Vitro and In Vivo

To improve the therapeutic potential of hepatocyte transplantation, the effects of the mitogen-activated protein kinase kinase 4 (MKK4) inhibitor, myricetin (3,3′,4′,5,5′,7-hexahydroxylflavone) were examined using porcine and human hepatocytes in vitro and in vivo. Hepatocytes were cultured, showing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Changhao, Enosawa, Shin, Matsunari, Hitomi, Nagashima, Hiroshi, Umezawa, Akihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940939/ https://www.ncbi.nlm.nih.gov/pubmed/31817281 http://dx.doi.org/10.3390/ijms20246123

Ejemplares similares

Myricetin: a Multifunctional Flavonol in Biomedicine
por: Agraharam, Gopikrishna, et al.
Publicado: (2022)

Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper
por: Sadžak, Anja, et al.
Publicado: (2021)

Application of hollow fiber vitrification for cryopreservation of bovine early cleavage stage embryos and porcine morula-blastomeres
por: UCHIKURA, Ayuko, et al.
Publicado: (2016)

Characterization and Treatment Responsiveness of Genetically Engineered Ornithine Transcarbamylase-Deficient Pig
por: Enosawa, Shin, et al.
Publicado: (2021)

Hollow fiber vitrification allows cryopreservation of embryos with compromised cryotolerance
por: Uchikura, Ayuko, et al.
Publicado: (2019)

Molecular Pathways Involved in the Anti-Cancer Activity of Flavonols: A Focus on Myricetin and Kaempferol
por: Felice, Maria Rosa, et al.
Publicado: (2022)

Cryopreservation of Fetal Porcine Kidneys for Xenogeneic Regenerative Medicine
por: Matsui, Kenji, et al.
Publicado: (2023)

Production of Diabetic Offspring Using Cryopreserved Epididymal Sperm by In Vitro Fertilization and Intrafallopian Insemination Techniques in Transgenic Pigs
por: UMEYAMA, Kazuhiro, et al.
Publicado: (2013)

Genetic Variation of Flavonols Quercetin, Myricetin, and Kaempferol in the Sri Lankan Tea (Camellia sinensis L.) and Their Health-Promoting Aspects
por: Jeganathan, Brasathe, et al.
Publicado: (2016)

Development of a Cryopreservation Technique for Xenogeneic Kidney Grafts: Evaluation Using a Mouse Model
por: Takamura, Tsuyoshi, et al.
Publicado: (2022)

Humanized liver mouse model with transplanted human hepatocytes from patients with ornithine transcarbamylase deficiency
por: Sugahara, Go, et al.
Publicado: (2020)

Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltransferase BGLU6
por: Ishihara, Hirofumi, et al.
Publicado: (2016)

Modeling lethal X-linked genetic disorders in pigs with ensured fertility
por: Matsunari, Hitomi, et al.
Publicado: (2018)

Two Myricetin-Derived Flavonols from Morella rubra Leaves as Potent α-Glucosidase Inhibitors and Structure-Activity Relationship Study by Computational Chemistry
por: Liu, Yilong, et al.
Publicado: (2022)

Barrier-promoting efficiency of two bioactive flavonols quercetin and myricetin on rat intestinal epithelial (IEC-6) cells via suppressing Rho activation
por: Fan, Jing, et al.
Publicado: (2020)

Myricetin enhance chemosensitivity of 5-fluorouracil on esophageal carcinoma in vitro and in vivo
por: Wang, Lei, et al.
Publicado: (2014)

Investigation of Clinical Safety of Human iPS Cell-Derived Liver Organoid Transplantation to Infantile Patients in Porcine Model
por: Tsuchida, Tomonori, et al.
Publicado: (2020)

Cryopreservation of Hepatocyte Microbeads for Clinical Transplantation
por: Jitraruch, Suttiruk, et al.
Publicado: (2017)

Effect of Myricetin on Lipid Metabolism in Primary Calf Hepatocytes Challenged with Long-Chain Fatty Acids
por: Yang, Wei, et al.
Publicado: (2022)

Inhibition of CpLIP2 Lipase Hydrolytic Activity by Four Flavonols (Galangin, Kaempferol, Quercetin, Myricetin) Compared to Orlistat and Their Binding Mechanisms Studied by Quenching of Fluorescence
por: Nasri, Ruba, et al.
Publicado: (2019)

Comparative cryopreservation of bovine and porcine primary hepatocytes
por: Andres, Sandra, et al.
Publicado: (2023)

Potential of natural flavonols and flavanones in the treatment of ulcerative colitis
por: Li, Cailan, et al.
Publicado: (2023)

Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies
por: Shibany, Khaled A., et al.
Publicado: (2016)

Anticancer effects of myricetin derivatives in non‐small cell lung cancer in vitro and in vivo
por: Li, Mengmeng, et al.
Publicado: (2021)

Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APC(Min/+) mice
por: Li, Ye, et al.
Publicado: (2016)

Dihydromyricetin hexaacetate
por: Li, Wei, et al.
Publicado: (2010)

Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia
por: Zhang, Li-Jie, et al.
Publicado: (2011)

Natural zwitterionic betaine enables cells to survive ultrarapid cryopreservation
por: Yang, Jing, et al.
Publicado: (2016)

Immortalization of human hepatocytes from biliary atresia with CDK4(R24C), cyclin D1, and TERT for cytochrome P450 induction testing
por: Nishiwaki, Manami, et al.
Publicado: (2020)

Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases
por: Mahmud, Aar Rafi, et al.
Publicado: (2023)

Characterization of the Brassica napus Flavonol Synthase Gene Family Reveals Bifunctional Flavonol Synthases
por: Schilbert, Hanna Marie, et al.
Publicado: (2021)

Regioselective Synthesis of Quercetin and Myricetin Derivatives
por: Pechinskii, S. V., et al.
Publicado: (2023)

The Impact of Flavonols on Cardiovascular Risk
por: Popiolek-Kalisz, Joanna, et al.
Publicado: (2022)

Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation
por: Hou, Yuzhen, et al.
Publicado: (2019)

Inhibition of African swine fever virus protease by myricetin and myricitrin
por: Jo, Seri, et al.
Publicado: (2020)

In Vitro Evaluation of Pro- and Antioxidant Effects of Flavonoid Tricetin in Comparison to Myricetin
por: Chobot, Vladimir, et al.
Publicado: (2020)

Effect of Myricetin on Primary Open-angle Glaucoma
por: Yang, Qing, et al.
Publicado: (2018)

Inhibitory Effects of Myricetin on Lipopolysaccharide-Induced Neuroinflammation
por: Jang, Jung-Hee, et al.
Publicado: (2020)

A Natural Dietary Flavone Myricetin as an α-Hemolysin Inhibitor for Controlling Staphylococcus aureus Infection
por: Wang, Tingting, et al.
Publicado: (2020)

In Vitro Evidence on Bioaccessibility of Flavonols and Cinnamoyl Derivatives of Cruciferous Sprouts
por: Abellán, Ángel, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jqnqa6un46ej5fnfpbjasefb84