Active Demethylation of Non-CpG Moieties in Animals: A Neglected Research Area

The functional role of cytosine methylation in the CpG moieties of DNA, is well established in several biological functions. The interplay between CpG methylation and hypomethylation is a well-known mechanism of modulation of gene expression. However, the role of non-CpG methylation and active dynam...

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Autores principales: Lucarelli, Marco, Ferraguti, Giampiero, Fuso, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940975/
https://www.ncbi.nlm.nih.gov/pubmed/31842376
http://dx.doi.org/10.3390/ijms20246272
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author Lucarelli, Marco
Ferraguti, Giampiero
Fuso, Andrea
author_facet Lucarelli, Marco
Ferraguti, Giampiero
Fuso, Andrea
author_sort Lucarelli, Marco
collection PubMed
description The functional role of cytosine methylation in the CpG moieties of DNA, is well established in several biological functions. The interplay between CpG methylation and hypomethylation is a well-known mechanism of modulation of gene expression. However, the role of non-CpG methylation and active dynamics of demethylation is not clearly recognized. Although some evidence exists of a role of active non-CpG demethylation in the fast dynamics of transcriptional activation in animals, few studies deal with this topic. At present, active demethylation of non-CpG moieties is a neglected research area, in spite of the promise of significant novelties.
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spelling pubmed-69409752020-01-09 Active Demethylation of Non-CpG Moieties in Animals: A Neglected Research Area Lucarelli, Marco Ferraguti, Giampiero Fuso, Andrea Int J Mol Sci Commentary The functional role of cytosine methylation in the CpG moieties of DNA, is well established in several biological functions. The interplay between CpG methylation and hypomethylation is a well-known mechanism of modulation of gene expression. However, the role of non-CpG methylation and active dynamics of demethylation is not clearly recognized. Although some evidence exists of a role of active non-CpG demethylation in the fast dynamics of transcriptional activation in animals, few studies deal with this topic. At present, active demethylation of non-CpG moieties is a neglected research area, in spite of the promise of significant novelties. MDPI 2019-12-12 /pmc/articles/PMC6940975/ /pubmed/31842376 http://dx.doi.org/10.3390/ijms20246272 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Lucarelli, Marco
Ferraguti, Giampiero
Fuso, Andrea
Active Demethylation of Non-CpG Moieties in Animals: A Neglected Research Area
title Active Demethylation of Non-CpG Moieties in Animals: A Neglected Research Area
title_full Active Demethylation of Non-CpG Moieties in Animals: A Neglected Research Area
title_fullStr Active Demethylation of Non-CpG Moieties in Animals: A Neglected Research Area
title_full_unstemmed Active Demethylation of Non-CpG Moieties in Animals: A Neglected Research Area
title_short Active Demethylation of Non-CpG Moieties in Animals: A Neglected Research Area
title_sort active demethylation of non-cpg moieties in animals: a neglected research area
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940975/
https://www.ncbi.nlm.nih.gov/pubmed/31842376
http://dx.doi.org/10.3390/ijms20246272
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