Do Mutations Turn p53 into an Oncogene?

The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but...

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Detalles Bibliográficos
Autores principales: Pitolli, Consuelo, Wang, Ying, Mancini, Mara, Shi, Yufang, Melino, Gerry, Amelio, Ivano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940991/
https://www.ncbi.nlm.nih.gov/pubmed/31835684
http://dx.doi.org/10.3390/ijms20246241
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author Pitolli, Consuelo
Wang, Ying
Mancini, Mara
Shi, Yufang
Melino, Gerry
Amelio, Ivano
author_facet Pitolli, Consuelo
Wang, Ying
Mancini, Mara
Shi, Yufang
Melino, Gerry
Amelio, Ivano
author_sort Pitolli, Consuelo
collection PubMed
description The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.
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spelling pubmed-69409912020-01-09 Do Mutations Turn p53 into an Oncogene? Pitolli, Consuelo Wang, Ying Mancini, Mara Shi, Yufang Melino, Gerry Amelio, Ivano Int J Mol Sci Review The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis. MDPI 2019-12-11 /pmc/articles/PMC6940991/ /pubmed/31835684 http://dx.doi.org/10.3390/ijms20246241 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pitolli, Consuelo
Wang, Ying
Mancini, Mara
Shi, Yufang
Melino, Gerry
Amelio, Ivano
Do Mutations Turn p53 into an Oncogene?
title Do Mutations Turn p53 into an Oncogene?
title_full Do Mutations Turn p53 into an Oncogene?
title_fullStr Do Mutations Turn p53 into an Oncogene?
title_full_unstemmed Do Mutations Turn p53 into an Oncogene?
title_short Do Mutations Turn p53 into an Oncogene?
title_sort do mutations turn p53 into an oncogene?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940991/
https://www.ncbi.nlm.nih.gov/pubmed/31835684
http://dx.doi.org/10.3390/ijms20246241
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AT shiyufang domutationsturnp53intoanoncogene
AT melinogerry domutationsturnp53intoanoncogene
AT amelioivano domutationsturnp53intoanoncogene

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