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Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update
Instability of the tear film (TF) protecting the ocular surface results in dry eye syndrome (DES), the most prevalent public health ophthalmic disease affecting the quality of life of 10 to 30% of the human population worldwide. Although the impact of the tear film lipid layer (TFLL) and of the aque...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941008/ https://www.ncbi.nlm.nih.gov/pubmed/31817367 http://dx.doi.org/10.3390/ijms20246132 |
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author | Georgiev, Georgi As. Eftimov, Petar Yokoi, Norihiko |
author_facet | Georgiev, Georgi As. Eftimov, Petar Yokoi, Norihiko |
author_sort | Georgiev, Georgi As. |
collection | PubMed |
description | Instability of the tear film (TF) protecting the ocular surface results in dry eye syndrome (DES), the most prevalent public health ophthalmic disease affecting the quality of life of 10 to 30% of the human population worldwide. Although the impact of the tear film lipid layer (TFLL) and of the aqueous tears (AT) to the TF stability is extensively studied, in contrast the contribution of the secretory mucins (SM) and of the membrane-associated mucins (MAM), i.e., one of the most abundant molecular classes in AT and in the corneal epithelium respectively, remains poorly defined. However, it is well known that in DES both types of mucins are quantitatively or qualitatively deficient. Numerous studies since the 1990s until now have proposed direct involvement of SM and MAM in the material properties (viscoelasticity, hydration, and protection of the ocular surface; synergistic cooperation with the rest of the TF layers; etc.) and stability of TF. These theories will be reviewed here in the context of the classical and modern in vitro and in vivo results that allow their reappraisal and in view of the novel mucin secretion enhancing pharmaceuticals, which have opened innovative routes for the therapy of DES. |
format | Online Article Text |
id | pubmed-6941008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69410082020-01-09 Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update Georgiev, Georgi As. Eftimov, Petar Yokoi, Norihiko Int J Mol Sci Review Instability of the tear film (TF) protecting the ocular surface results in dry eye syndrome (DES), the most prevalent public health ophthalmic disease affecting the quality of life of 10 to 30% of the human population worldwide. Although the impact of the tear film lipid layer (TFLL) and of the aqueous tears (AT) to the TF stability is extensively studied, in contrast the contribution of the secretory mucins (SM) and of the membrane-associated mucins (MAM), i.e., one of the most abundant molecular classes in AT and in the corneal epithelium respectively, remains poorly defined. However, it is well known that in DES both types of mucins are quantitatively or qualitatively deficient. Numerous studies since the 1990s until now have proposed direct involvement of SM and MAM in the material properties (viscoelasticity, hydration, and protection of the ocular surface; synergistic cooperation with the rest of the TF layers; etc.) and stability of TF. These theories will be reviewed here in the context of the classical and modern in vitro and in vivo results that allow their reappraisal and in view of the novel mucin secretion enhancing pharmaceuticals, which have opened innovative routes for the therapy of DES. MDPI 2019-12-05 /pmc/articles/PMC6941008/ /pubmed/31817367 http://dx.doi.org/10.3390/ijms20246132 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Georgiev, Georgi As. Eftimov, Petar Yokoi, Norihiko Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update |
title | Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update |
title_full | Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update |
title_fullStr | Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update |
title_full_unstemmed | Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update |
title_short | Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update |
title_sort | contribution of mucins towards the physical properties of the tear film: a modern update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941008/ https://www.ncbi.nlm.nih.gov/pubmed/31817367 http://dx.doi.org/10.3390/ijms20246132 |
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