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Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update

Instability of the tear film (TF) protecting the ocular surface results in dry eye syndrome (DES), the most prevalent public health ophthalmic disease affecting the quality of life of 10 to 30% of the human population worldwide. Although the impact of the tear film lipid layer (TFLL) and of the aque...

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Autores principales: Georgiev, Georgi As., Eftimov, Petar, Yokoi, Norihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941008/
https://www.ncbi.nlm.nih.gov/pubmed/31817367
http://dx.doi.org/10.3390/ijms20246132
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author Georgiev, Georgi As.
Eftimov, Petar
Yokoi, Norihiko
author_facet Georgiev, Georgi As.
Eftimov, Petar
Yokoi, Norihiko
author_sort Georgiev, Georgi As.
collection PubMed
description Instability of the tear film (TF) protecting the ocular surface results in dry eye syndrome (DES), the most prevalent public health ophthalmic disease affecting the quality of life of 10 to 30% of the human population worldwide. Although the impact of the tear film lipid layer (TFLL) and of the aqueous tears (AT) to the TF stability is extensively studied, in contrast the contribution of the secretory mucins (SM) and of the membrane-associated mucins (MAM), i.e., one of the most abundant molecular classes in AT and in the corneal epithelium respectively, remains poorly defined. However, it is well known that in DES both types of mucins are quantitatively or qualitatively deficient. Numerous studies since the 1990s until now have proposed direct involvement of SM and MAM in the material properties (viscoelasticity, hydration, and protection of the ocular surface; synergistic cooperation with the rest of the TF layers; etc.) and stability of TF. These theories will be reviewed here in the context of the classical and modern in vitro and in vivo results that allow their reappraisal and in view of the novel mucin secretion enhancing pharmaceuticals, which have opened innovative routes for the therapy of DES.
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spelling pubmed-69410082020-01-09 Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update Georgiev, Georgi As. Eftimov, Petar Yokoi, Norihiko Int J Mol Sci Review Instability of the tear film (TF) protecting the ocular surface results in dry eye syndrome (DES), the most prevalent public health ophthalmic disease affecting the quality of life of 10 to 30% of the human population worldwide. Although the impact of the tear film lipid layer (TFLL) and of the aqueous tears (AT) to the TF stability is extensively studied, in contrast the contribution of the secretory mucins (SM) and of the membrane-associated mucins (MAM), i.e., one of the most abundant molecular classes in AT and in the corneal epithelium respectively, remains poorly defined. However, it is well known that in DES both types of mucins are quantitatively or qualitatively deficient. Numerous studies since the 1990s until now have proposed direct involvement of SM and MAM in the material properties (viscoelasticity, hydration, and protection of the ocular surface; synergistic cooperation with the rest of the TF layers; etc.) and stability of TF. These theories will be reviewed here in the context of the classical and modern in vitro and in vivo results that allow their reappraisal and in view of the novel mucin secretion enhancing pharmaceuticals, which have opened innovative routes for the therapy of DES. MDPI 2019-12-05 /pmc/articles/PMC6941008/ /pubmed/31817367 http://dx.doi.org/10.3390/ijms20246132 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Georgiev, Georgi As.
Eftimov, Petar
Yokoi, Norihiko
Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update
title Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update
title_full Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update
title_fullStr Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update
title_full_unstemmed Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update
title_short Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update
title_sort contribution of mucins towards the physical properties of the tear film: a modern update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941008/
https://www.ncbi.nlm.nih.gov/pubmed/31817367
http://dx.doi.org/10.3390/ijms20246132
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