Primary Neurons and Differentiated NSC-34 Cells Are More Susceptible to Arginine-Rich ALS Dipeptide Repeat Protein-Associated Toxicity than Non-Differentiated NSC-34 and CHO Cells

A repeat expansion mutation in the C9orf72 gene is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In this study, using multiple cell-based assay systems, we reveal both increased dipeptide repeat protein (DRP) toxicity in primary neurons...

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Detalles Bibliográficos
Autores principales: Gill, Anna L., Wang, Monica Z., Levine, Beth, Premasiri, Alan, Vieira, Fernando G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941034/
https://www.ncbi.nlm.nih.gov/pubmed/31835664
http://dx.doi.org/10.3390/ijms20246238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941034/
https://www.ncbi.nlm.nih.gov/pubmed/31835664
http://dx.doi.org/10.3390/ijms20246238

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