Cargando…

Depletion of Akt1 and Akt2 Impairs the Repair of Radiation-Induced DNA Double Strand Breaks via Homologous Recombination

Homologous recombination repair (HRR), non-homologous end-joining (NHEJ) and alternative NHEJ are major pathways that are utilized by cells for processing DNA double strand breaks (DNA-DSBs); their function plays an important role in the radiation resistance of tumor cells. Conflicting data exist re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mohammadian Gol, Tahereh, Rodemann, H. Peter, Dittmann, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941063/ https://www.ncbi.nlm.nih.gov/pubmed/31847370 http://dx.doi.org/10.3390/ijms20246316

Ejemplares similares

Akt1 Stimulates Homologous Recombination Repair of DNA Double-Strand Breaks in a Rad51-Dependent Manner
por: Mueck, Katharina, et al.
Publicado: (2017)

Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells
por: Holler, Marina, et al.
Publicado: (2016)

Aging impairs double‐strand break repair by homologous recombination in Drosophila germ cells
por: Delabaere, Laetitia, et al.
Publicado: (2016)

Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks
por: Hawtin, Rachael Elizabeth, et al.
Publicado: (2010)

CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair
por: Hilmi, Khalid, et al.
Publicado: (2017)

Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation
por: Groth, Petra, et al.
Publicado: (2012)

Ctf18 is required for homologous recombination-mediated double-strand break repair
por: Ogiwara, Hideaki, et al.
Publicado: (2007)

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
por: Bolderson, Emma, et al.
Publicado: (2010)

DNA double-strand break repair in Penaeus monodon is predominantly dependent on homologous recombination
por: Srivastava, Shikha, et al.
Publicado: (2017)

CTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks
por: Hwang, Soon Young, et al.
Publicado: (2019)

Centriolar subdistal appendages promote double‐strand break repair through homologous recombination
por: Rodríguez‐Real, Guillermo, et al.
Publicado: (2023)

Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity
por: Oeck, S., et al.
Publicado: (2017)

SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination
por: Bolcun-Filas, Ewelina, et al.
Publicado: (2007)

A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks
por: Li, Bingbing X., et al.
Publicado: (2018)

Chromosome Preference During Homologous Recombination Repair of DNA Double-Strand Breaks in Drosophila melanogaster
por: Fernandez, Joel, et al.
Publicado: (2019)

Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase
por: Köcher, Sabrina, et al.
Publicado: (2012)

Pre-Exposure to Ionizing Radiation Stimulates DNA Double Strand Break End Resection, Promoting the Use of Homologous Recombination Repair
por: Nakajima, Nakako Izumi, et al.
Publicado: (2015)

The Role of DNA Double-Strand Breaks in Spontaneous Homologous Recombination in S. cerevisiae
por: Lettier, Gaëlle, et al.
Publicado: (2006)

Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination
por: Gao, Min, et al.
Publicado: (2014)

Subtelomeric I-SceI-Mediated Double-Strand Breaks Are Repaired by Homologous Recombination in Trypanosoma cruzi
por: Chiurillo, Miguel A., et al.
Publicado: (2016)

Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair
por: Sizemore, Steven T., et al.
Publicado: (2018)

ZmRAD51C Is Essential for Double-Strand Break Repair and Homologous Recombination in Maize Meiosis
por: Jing, Juli, et al.
Publicado: (2019)

The Safe Path at the Fork: Ensuring Replication-Associated DNA Double-Strand Breaks are Repaired by Homologous Recombination
por: Nickoloff, Jac A., et al.
Publicado: (2021)

Recombinational repair of radiation-induced double-strand breaks occurs in the absence of extensive resection
por: Westmoreland, James W., et al.
Publicado: (2016)

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
por: Beucher, Andrea, et al.
Publicado: (2009)

Homologous recombination pathway may play a major role in high-LET radiation-induced DNA double-strand break repair
por: Gerelchuluun, Ariungerel, et al.
Publicado: (2014)

The Efficiency of Homologous Recombination and Non-Homologous End Joining Systems in Repairing Double-Strand Breaks during Cell Cycle Progression
por: Bee, Leonardo, et al.
Publicado: (2013)

Homologous recombination repair intermediates promote efficient de novo telomere addition at DNA double-strand breaks
por: Davé, Anoushka, et al.
Publicado: (2020)

Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells
por: Szymonowicz, Klaudia, et al.
Publicado: (2018)

Either Non-Homologous Ends Joining or Homologous Recombination Is Required to Repair Double-Strand Breaks in the Genome of Macrophage-Internalized Mycobacterium tuberculosis
por: Brzostek, Anna, et al.
Publicado: (2014)

Mutation in DDM1 inhibits the homology directed repair of double strand breaks
por: Choi, Seung Hee, et al.
Publicado: (2019)

Optimizing the DNA Donor Template for Homology-Directed Repair of Double-Strand Breaks
por: Song, Fei, et al.
Publicado: (2017)

GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination
por: Takizawa, Yoshimasa, et al.
Publicado: (2010)

CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms
por: Brunner, Erich, et al.
Publicado: (2019)

5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair
por: Srinivas, Upadhyayula Sai, et al.
Publicado: (2015)

Members of the RAD52 Epistasis Group Contribute to Mitochondrial Homologous Recombination and Double-Strand Break Repair in Saccharomyces cerevisiae
por: Stein, Alexis, et al.
Publicado: (2015)

Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes
por: He, Da-Jian, et al.
Publicado: (2018)

AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway
por: Lou, Jiangman, et al.
Publicado: (2017)

Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks
por: Vriend, Lianne E.M., et al.
Publicado: (2016)

RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs
por: Machour, Feras E, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ho5ic8g9iqk1vr6ii6rtknt0nq