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Efficient Rapid Access to Biginelli for the Multicomponent Synthesis of 1,2,3,4-Tetrahydropyrimidines in Room-Temperature Diisopropyl Ethyl Ammonium Acetate

[Image: see text] The diisopropyl ethyl ammonium acetate (DIPEAc)-promoted Biginelli protocol has been developed for the first time by a successive one-pot three-component reaction of aldehydes, ethylcyanoacetate/ethyl acetoacetate, and thiourea/urea to afford pharmacologically promising 1,2,3,4-tet...

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Detalles Bibliográficos
Autores principales: Jadhav, Chetan K., Nipate, Amol S., Chate, Asha V., Songire, Vishal D., Patil, Anil P., Gill, Charansingh. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941212/
https://www.ncbi.nlm.nih.gov/pubmed/31909314
http://dx.doi.org/10.1021/acsomega.9b02286