Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity

The broadly neutralizing anti-HIV antibody, 10-1074, is a highly somatically hypermutated IgG1 being developed for prophylaxis in sub-Saharan Africa. A series of algorithms were applied to identify potentially destabilizing residues in the framework of the Fv region. Of 17 residues defined, a varian...

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Detalles Bibliográficos
Autores principales: Kerwin, Bruce A., Bennett, Chelsey, Brodsky, Yan, Clark, Rutilio, Floyd, J. Alaina, Gillespie, Alison, Mayer, Bryan T., McClure, Megan, Siska, Christine, Seaman, Michael S., Seaton, Kelly E., Shaver, Jeremy, Tomaras, Georgia D., Yates, Nicole L., Ketchem, Randal R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941225/
https://www.ncbi.nlm.nih.gov/pubmed/31348937
http://dx.doi.org/10.1016/j.xphs.2019.07.009

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