Cargando…

Clinical analysis of Kimura’s disease in 24 cases from China

BACKGROUND: We reviewed details of Chinese Kimura’s disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD. METHODS: A total of 24 patients with pathologically confirmed KD treated between March 2008 and March 2018 we...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Guoliang, Li, Xumao, Sun, Guangbin, Cao, Yitan, Gao, Nan, Qi, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941305/
https://www.ncbi.nlm.nih.gov/pubmed/31898499
http://dx.doi.org/10.1186/s12893-019-0673-7
_version_ 1783484527356674048
author Zhang, Guoliang
Li, Xumao
Sun, Guangbin
Cao, Yitan
Gao, Nan
Qi, Weidong
author_facet Zhang, Guoliang
Li, Xumao
Sun, Guangbin
Cao, Yitan
Gao, Nan
Qi, Weidong
author_sort Zhang, Guoliang
collection PubMed
description BACKGROUND: We reviewed details of Chinese Kimura’s disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD. METHODS: A total of 24 patients with pathologically confirmed KD treated between March 2008 and March 2018 were reviewed retrospectively for clinical and histopathological analysis. RESULTS: In the 24 KD cases, 20 were male and 4 were female with the age of onset ranging from 5 to 65 years. Lesion diameter ranged from 0.6 cm to 7 cm with unilateral involvement being more popular (79%). Imaging examination had a high detection rate for KD involving the parotid gland and subcutaneous but had low specificity. Microscopic analysis indicated that KD mainly involved subcutaneous soft tissue and lymph nodes. The prominent feature of lymphoid tissue was germinal center hyperplasia surrounded by several lobules associated with hyperplastic vascular structures. Out of the 24 patients, 11 experienced recurrence of disease after treatment (surgical resection: 46.2%, surgical resection followed by oral corticosteroids: 71.4% and surgical resection combined with radiotherapy: 0%). CONCLUSIONS: Our analysis revealed clinical, imaging, and histological characteristics of KD. A better understanding of the disease will help clinicians reduce misdiagnosis and improve the diagnostic rate upon patient first clinical visit.
format Online
Article
Text
id pubmed-6941305
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-69413052020-01-06 Clinical analysis of Kimura’s disease in 24 cases from China Zhang, Guoliang Li, Xumao Sun, Guangbin Cao, Yitan Gao, Nan Qi, Weidong BMC Surg Research Article BACKGROUND: We reviewed details of Chinese Kimura’s disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD. METHODS: A total of 24 patients with pathologically confirmed KD treated between March 2008 and March 2018 were reviewed retrospectively for clinical and histopathological analysis. RESULTS: In the 24 KD cases, 20 were male and 4 were female with the age of onset ranging from 5 to 65 years. Lesion diameter ranged from 0.6 cm to 7 cm with unilateral involvement being more popular (79%). Imaging examination had a high detection rate for KD involving the parotid gland and subcutaneous but had low specificity. Microscopic analysis indicated that KD mainly involved subcutaneous soft tissue and lymph nodes. The prominent feature of lymphoid tissue was germinal center hyperplasia surrounded by several lobules associated with hyperplastic vascular structures. Out of the 24 patients, 11 experienced recurrence of disease after treatment (surgical resection: 46.2%, surgical resection followed by oral corticosteroids: 71.4% and surgical resection combined with radiotherapy: 0%). CONCLUSIONS: Our analysis revealed clinical, imaging, and histological characteristics of KD. A better understanding of the disease will help clinicians reduce misdiagnosis and improve the diagnostic rate upon patient first clinical visit. BioMed Central 2020-01-02 /pmc/articles/PMC6941305/ /pubmed/31898499 http://dx.doi.org/10.1186/s12893-019-0673-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhang, Guoliang
Li, Xumao
Sun, Guangbin
Cao, Yitan
Gao, Nan
Qi, Weidong
Clinical analysis of Kimura’s disease in 24 cases from China
title Clinical analysis of Kimura’s disease in 24 cases from China
title_full Clinical analysis of Kimura’s disease in 24 cases from China
title_fullStr Clinical analysis of Kimura’s disease in 24 cases from China
title_full_unstemmed Clinical analysis of Kimura’s disease in 24 cases from China
title_short Clinical analysis of Kimura’s disease in 24 cases from China
title_sort clinical analysis of kimura’s disease in 24 cases from china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941305/
https://www.ncbi.nlm.nih.gov/pubmed/31898499
http://dx.doi.org/10.1186/s12893-019-0673-7
work_keys_str_mv AT zhangguoliang clinicalanalysisofkimurasdiseasein24casesfromchina
AT lixumao clinicalanalysisofkimurasdiseasein24casesfromchina
AT sunguangbin clinicalanalysisofkimurasdiseasein24casesfromchina
AT caoyitan clinicalanalysisofkimurasdiseasein24casesfromchina
AT gaonan clinicalanalysisofkimurasdiseasein24casesfromchina
AT qiweidong clinicalanalysisofkimurasdiseasein24casesfromchina