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Selenium Level in Patients with Heart Failure versus Normal Individuals
BACKGROUND: Despite many attempts to discover pathophysiologic mechanisms to explain chronic heart failure (CHF), no conceptual paradigms have been proved yet. Various studies have shown the role of trace elements on heart failure (HF). Among all trace elements, selenium deficiency is regarded as im...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941308/ https://www.ncbi.nlm.nih.gov/pubmed/31921402 http://dx.doi.org/10.4103/ijpvm.IJPVM_45_18 |
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author | Mirdamadi, Ahmad Rafiei, Rahmatollah Kahazaipour, Gharae Fouladi, Lotfollah |
author_facet | Mirdamadi, Ahmad Rafiei, Rahmatollah Kahazaipour, Gharae Fouladi, Lotfollah |
author_sort | Mirdamadi, Ahmad |
collection | PubMed |
description | BACKGROUND: Despite many attempts to discover pathophysiologic mechanisms to explain chronic heart failure (CHF), no conceptual paradigms have been proved yet. Various studies have shown the role of trace elements on heart failure (HF). Among all trace elements, selenium deficiency is regarded as important risk factors for HF. Considering selenium deficiency in our society and high prevalence of HF, we compared selenium level in patients with HF with healthy individuals. METHODS: In all, 32 hospitalized patients with HF and 32 healthy controls were enrolled in a case–control study. Demographic characteristics as well as functional class and risk factors were recorded for all two groups. Echocardiography was conducted for patients and all provided data were registered. Then serum selenium levels were compared in case and control groups. RESULTS: The mean (±standard deviation) serum selenium was 92.5 ± 22.44 mg/dL in patients with HF and 109.3 ± 29.62 mg/dL in controls. The level of selenium was significantly lower and the frequency of risk factors was significantly higher in case group. Selenium level did not differ significantly in patients with different HF causes. There were a nonsignificant relationship between selenium level and left ventricular ejection fraction and a significant reverse relationship between selenium level and left ventricular volume and pulmonary artery pressure. CONCLUSIONS: Our results showed statistically significant lower level of serum selenium in patients with CHF in comparison to normal individuals. Moreover, selenium level had significant reverse relationship with left ventricular volume and pulmonary artery pressure. |
format | Online Article Text |
id | pubmed-6941308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-69413082020-01-09 Selenium Level in Patients with Heart Failure versus Normal Individuals Mirdamadi, Ahmad Rafiei, Rahmatollah Kahazaipour, Gharae Fouladi, Lotfollah Int J Prev Med Original Article BACKGROUND: Despite many attempts to discover pathophysiologic mechanisms to explain chronic heart failure (CHF), no conceptual paradigms have been proved yet. Various studies have shown the role of trace elements on heart failure (HF). Among all trace elements, selenium deficiency is regarded as important risk factors for HF. Considering selenium deficiency in our society and high prevalence of HF, we compared selenium level in patients with HF with healthy individuals. METHODS: In all, 32 hospitalized patients with HF and 32 healthy controls were enrolled in a case–control study. Demographic characteristics as well as functional class and risk factors were recorded for all two groups. Echocardiography was conducted for patients and all provided data were registered. Then serum selenium levels were compared in case and control groups. RESULTS: The mean (±standard deviation) serum selenium was 92.5 ± 22.44 mg/dL in patients with HF and 109.3 ± 29.62 mg/dL in controls. The level of selenium was significantly lower and the frequency of risk factors was significantly higher in case group. Selenium level did not differ significantly in patients with different HF causes. There were a nonsignificant relationship between selenium level and left ventricular ejection fraction and a significant reverse relationship between selenium level and left ventricular volume and pulmonary artery pressure. CONCLUSIONS: Our results showed statistically significant lower level of serum selenium in patients with CHF in comparison to normal individuals. Moreover, selenium level had significant reverse relationship with left ventricular volume and pulmonary artery pressure. Wolters Kluwer - Medknow 2019-12-10 /pmc/articles/PMC6941308/ /pubmed/31921402 http://dx.doi.org/10.4103/ijpvm.IJPVM_45_18 Text en Copyright: © 2019 International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Mirdamadi, Ahmad Rafiei, Rahmatollah Kahazaipour, Gharae Fouladi, Lotfollah Selenium Level in Patients with Heart Failure versus Normal Individuals |
title | Selenium Level in Patients with Heart Failure versus Normal Individuals |
title_full | Selenium Level in Patients with Heart Failure versus Normal Individuals |
title_fullStr | Selenium Level in Patients with Heart Failure versus Normal Individuals |
title_full_unstemmed | Selenium Level in Patients with Heart Failure versus Normal Individuals |
title_short | Selenium Level in Patients with Heart Failure versus Normal Individuals |
title_sort | selenium level in patients with heart failure versus normal individuals |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941308/ https://www.ncbi.nlm.nih.gov/pubmed/31921402 http://dx.doi.org/10.4103/ijpvm.IJPVM_45_18 |
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