Two new aromatic polyketides from a sponge-derived Fusarium

In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3–7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these com...

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Detalles Bibliográficos
Autores principales: Sibero, Mada Triandala, Zhou, Tao, Fukaya, Keisuke, Urabe, Daisuke, Radjasa, Ocky K Karna, Sabdono, Agus, Trianto, Agus, Igarashi, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941419/
https://www.ncbi.nlm.nih.gov/pubmed/31921365
http://dx.doi.org/10.3762/bjoc.15.289
Descripción
Sumario:In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3–7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these compounds were determined by the analysis of NMR and MS spectroscopic data. The NMR assignment of 1 was assisted by DFT-based theoretical chemical shift calculation. Compound 2 showed antibacterial activity against multidrug resistant Salmonella enterica ser. Typhi with a MIC of 125 µg/mL while 1 was not active.

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