Two new aromatic polyketides from a sponge-derived Fusarium

In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3–7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these com...

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Autores principales: Sibero, Mada Triandala, Zhou, Tao, Fukaya, Keisuke, Urabe, Daisuke, Radjasa, Ocky K Karna, Sabdono, Agus, Trianto, Agus, Igarashi, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941419/
https://www.ncbi.nlm.nih.gov/pubmed/31921365
http://dx.doi.org/10.3762/bjoc.15.289
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author Sibero, Mada Triandala
Zhou, Tao
Fukaya, Keisuke
Urabe, Daisuke
Radjasa, Ocky K Karna
Sabdono, Agus
Trianto, Agus
Igarashi, Yasuhiro
author_facet Sibero, Mada Triandala
Zhou, Tao
Fukaya, Keisuke
Urabe, Daisuke
Radjasa, Ocky K Karna
Sabdono, Agus
Trianto, Agus
Igarashi, Yasuhiro
author_sort Sibero, Mada Triandala
collection PubMed
description In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3–7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these compounds were determined by the analysis of NMR and MS spectroscopic data. The NMR assignment of 1 was assisted by DFT-based theoretical chemical shift calculation. Compound 2 showed antibacterial activity against multidrug resistant Salmonella enterica ser. Typhi with a MIC of 125 µg/mL while 1 was not active.
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spelling pubmed-69414192020-01-09 Two new aromatic polyketides from a sponge-derived Fusarium Sibero, Mada Triandala Zhou, Tao Fukaya, Keisuke Urabe, Daisuke Radjasa, Ocky K Karna Sabdono, Agus Trianto, Agus Igarashi, Yasuhiro Beilstein J Org Chem Full Research Paper In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3–7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these compounds were determined by the analysis of NMR and MS spectroscopic data. The NMR assignment of 1 was assisted by DFT-based theoretical chemical shift calculation. Compound 2 showed antibacterial activity against multidrug resistant Salmonella enterica ser. Typhi with a MIC of 125 µg/mL while 1 was not active. Beilstein-Institut 2019-12-09 /pmc/articles/PMC6941419/ /pubmed/31921365 http://dx.doi.org/10.3762/bjoc.15.289 Text en Copyright © 2019, Sibero et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Sibero, Mada Triandala
Zhou, Tao
Fukaya, Keisuke
Urabe, Daisuke
Radjasa, Ocky K Karna
Sabdono, Agus
Trianto, Agus
Igarashi, Yasuhiro
Two new aromatic polyketides from a sponge-derived Fusarium
title Two new aromatic polyketides from a sponge-derived Fusarium
title_full Two new aromatic polyketides from a sponge-derived Fusarium
title_fullStr Two new aromatic polyketides from a sponge-derived Fusarium
title_full_unstemmed Two new aromatic polyketides from a sponge-derived Fusarium
title_short Two new aromatic polyketides from a sponge-derived Fusarium
title_sort two new aromatic polyketides from a sponge-derived fusarium
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941419/
https://www.ncbi.nlm.nih.gov/pubmed/31921365
http://dx.doi.org/10.3762/bjoc.15.289
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