Cargando…
Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts
Ultraviolet B (UVB) irradiation-induced photoaging leads to wrinkles, dryness, and skin roughness. UVB irradiation activates the production of reactive oxygen species (ROS) and stimulates the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway, which promotes express...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Food Science and Nutrition
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941729/ https://www.ncbi.nlm.nih.gov/pubmed/31915640 http://dx.doi.org/10.3746/pnf.2019.24.4.442 |
_version_ | 1783484591677374464 |
---|---|
author | Seo, Heewon Kim, Changhee Kim, Mi-Bo Hwang, Jae-Kwan |
author_facet | Seo, Heewon Kim, Changhee Kim, Mi-Bo Hwang, Jae-Kwan |
author_sort | Seo, Heewon |
collection | PubMed |
description | Ultraviolet B (UVB) irradiation-induced photoaging leads to wrinkles, dryness, and skin roughness. UVB irradiation activates the production of reactive oxygen species (ROS) and stimulates the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway, which promotes expression of matrix metalloproteinases (MMPs) and inflammatory cytokines. The current study aimed to assess the anti-photoaging activity of Agastache rugosa extract (ARE) on UVB-treated human dermal fibroblasts. ARE treatment reduced the overproduction of ROS and promoted mRNA expression of anti-oxidant enzymes. ARE treatment significantly inactivated the MAPK/AP-1 signaling pathway, which downregulated the expression of MMPs. Moreover, ARE promoted the production of type-I procollagen and upregulated mRNA expression of collagen genes. Additionally, ARE suppressed the expression of inflammatory cytokines, including interleukin (IL)-1β, IL-6, and IL-8, by preventing expression of nuclear factor-kappa B. Collectively, our findings show that ARE could be a potential candidate for anti-photoaging treatment. |
format | Online Article Text |
id | pubmed-6941729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Korean Society of Food Science and Nutrition |
record_format | MEDLINE/PubMed |
spelling | pubmed-69417292020-01-08 Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts Seo, Heewon Kim, Changhee Kim, Mi-Bo Hwang, Jae-Kwan Prev Nutr Food Sci Articles Ultraviolet B (UVB) irradiation-induced photoaging leads to wrinkles, dryness, and skin roughness. UVB irradiation activates the production of reactive oxygen species (ROS) and stimulates the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway, which promotes expression of matrix metalloproteinases (MMPs) and inflammatory cytokines. The current study aimed to assess the anti-photoaging activity of Agastache rugosa extract (ARE) on UVB-treated human dermal fibroblasts. ARE treatment reduced the overproduction of ROS and promoted mRNA expression of anti-oxidant enzymes. ARE treatment significantly inactivated the MAPK/AP-1 signaling pathway, which downregulated the expression of MMPs. Moreover, ARE promoted the production of type-I procollagen and upregulated mRNA expression of collagen genes. Additionally, ARE suppressed the expression of inflammatory cytokines, including interleukin (IL)-1β, IL-6, and IL-8, by preventing expression of nuclear factor-kappa B. Collectively, our findings show that ARE could be a potential candidate for anti-photoaging treatment. The Korean Society of Food Science and Nutrition 2019-12 2019-12-31 /pmc/articles/PMC6941729/ /pubmed/31915640 http://dx.doi.org/10.3746/pnf.2019.24.4.442 Text en Copyright © 2019 by The Korean Society of Food Science and Nutrition This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Seo, Heewon Kim, Changhee Kim, Mi-Bo Hwang, Jae-Kwan Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts |
title | Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts |
title_full | Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts |
title_fullStr | Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts |
title_full_unstemmed | Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts |
title_short | Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts |
title_sort | anti-photoaging effect of korean mint (agastache rugosa kuntze) extract on uvb-irradiated human dermal fibroblasts |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941729/ https://www.ncbi.nlm.nih.gov/pubmed/31915640 http://dx.doi.org/10.3746/pnf.2019.24.4.442 |
work_keys_str_mv | AT seoheewon antiphotoagingeffectofkoreanmintagastacherugosakuntzeextractonuvbirradiatedhumandermalfibroblasts AT kimchanghee antiphotoagingeffectofkoreanmintagastacherugosakuntzeextractonuvbirradiatedhumandermalfibroblasts AT kimmibo antiphotoagingeffectofkoreanmintagastacherugosakuntzeextractonuvbirradiatedhumandermalfibroblasts AT hwangjaekwan antiphotoagingeffectofkoreanmintagastacherugosakuntzeextractonuvbirradiatedhumandermalfibroblasts |