Cargando…

Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts

Ultraviolet B (UVB) irradiation-induced photoaging leads to wrinkles, dryness, and skin roughness. UVB irradiation activates the production of reactive oxygen species (ROS) and stimulates the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway, which promotes express...

Descripción completa

Detalles Bibliográficos
Autores principales: Seo, Heewon, Kim, Changhee, Kim, Mi-Bo, Hwang, Jae-Kwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Food Science and Nutrition 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941729/
https://www.ncbi.nlm.nih.gov/pubmed/31915640
http://dx.doi.org/10.3746/pnf.2019.24.4.442
_version_ 1783484591677374464
author Seo, Heewon
Kim, Changhee
Kim, Mi-Bo
Hwang, Jae-Kwan
author_facet Seo, Heewon
Kim, Changhee
Kim, Mi-Bo
Hwang, Jae-Kwan
author_sort Seo, Heewon
collection PubMed
description Ultraviolet B (UVB) irradiation-induced photoaging leads to wrinkles, dryness, and skin roughness. UVB irradiation activates the production of reactive oxygen species (ROS) and stimulates the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway, which promotes expression of matrix metalloproteinases (MMPs) and inflammatory cytokines. The current study aimed to assess the anti-photoaging activity of Agastache rugosa extract (ARE) on UVB-treated human dermal fibroblasts. ARE treatment reduced the overproduction of ROS and promoted mRNA expression of anti-oxidant enzymes. ARE treatment significantly inactivated the MAPK/AP-1 signaling pathway, which downregulated the expression of MMPs. Moreover, ARE promoted the production of type-I procollagen and upregulated mRNA expression of collagen genes. Additionally, ARE suppressed the expression of inflammatory cytokines, including interleukin (IL)-1β, IL-6, and IL-8, by preventing expression of nuclear factor-kappa B. Collectively, our findings show that ARE could be a potential candidate for anti-photoaging treatment.
format Online
Article
Text
id pubmed-6941729
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher The Korean Society of Food Science and Nutrition
record_format MEDLINE/PubMed
spelling pubmed-69417292020-01-08 Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts Seo, Heewon Kim, Changhee Kim, Mi-Bo Hwang, Jae-Kwan Prev Nutr Food Sci Articles Ultraviolet B (UVB) irradiation-induced photoaging leads to wrinkles, dryness, and skin roughness. UVB irradiation activates the production of reactive oxygen species (ROS) and stimulates the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway, which promotes expression of matrix metalloproteinases (MMPs) and inflammatory cytokines. The current study aimed to assess the anti-photoaging activity of Agastache rugosa extract (ARE) on UVB-treated human dermal fibroblasts. ARE treatment reduced the overproduction of ROS and promoted mRNA expression of anti-oxidant enzymes. ARE treatment significantly inactivated the MAPK/AP-1 signaling pathway, which downregulated the expression of MMPs. Moreover, ARE promoted the production of type-I procollagen and upregulated mRNA expression of collagen genes. Additionally, ARE suppressed the expression of inflammatory cytokines, including interleukin (IL)-1β, IL-6, and IL-8, by preventing expression of nuclear factor-kappa B. Collectively, our findings show that ARE could be a potential candidate for anti-photoaging treatment. The Korean Society of Food Science and Nutrition 2019-12 2019-12-31 /pmc/articles/PMC6941729/ /pubmed/31915640 http://dx.doi.org/10.3746/pnf.2019.24.4.442 Text en Copyright © 2019 by The Korean Society of Food Science and Nutrition This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Seo, Heewon
Kim, Changhee
Kim, Mi-Bo
Hwang, Jae-Kwan
Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts
title Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts
title_full Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts
title_fullStr Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts
title_full_unstemmed Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts
title_short Anti-Photoaging Effect of Korean Mint (Agastache rugosa Kuntze) Extract on UVB-Irradiated Human Dermal Fibroblasts
title_sort anti-photoaging effect of korean mint (agastache rugosa kuntze) extract on uvb-irradiated human dermal fibroblasts
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941729/
https://www.ncbi.nlm.nih.gov/pubmed/31915640
http://dx.doi.org/10.3746/pnf.2019.24.4.442
work_keys_str_mv AT seoheewon antiphotoagingeffectofkoreanmintagastacherugosakuntzeextractonuvbirradiatedhumandermalfibroblasts
AT kimchanghee antiphotoagingeffectofkoreanmintagastacherugosakuntzeextractonuvbirradiatedhumandermalfibroblasts
AT kimmibo antiphotoagingeffectofkoreanmintagastacherugosakuntzeextractonuvbirradiatedhumandermalfibroblasts
AT hwangjaekwan antiphotoagingeffectofkoreanmintagastacherugosakuntzeextractonuvbirradiatedhumandermalfibroblasts