Current estimates of T cell kinetics in humans

Stable isotope labeling is a generally applicable method of quantifying cell dynamics. Its advent has opened up the way for the quantitative study of T cells in humans. However, the literature is confusing as estimates vary by orders of magnitude between studies. In this short review we aim to expla...

Descripción completa

Detalles Bibliográficos
Autores principales: Macallan, Derek C., Busch, Robert, Asquith, Becca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941842/
https://www.ncbi.nlm.nih.gov/pubmed/31922055
http://dx.doi.org/10.1016/j.coisb.2019.10.002
_version_ 1783484608195592192
author Macallan, Derek C.
Busch, Robert
Asquith, Becca
author_facet Macallan, Derek C.
Busch, Robert
Asquith, Becca
author_sort Macallan, Derek C.
collection PubMed
description Stable isotope labeling is a generally applicable method of quantifying cell dynamics. Its advent has opened up the way for the quantitative study of T cells in humans. However, the literature is confusing as estimates vary by orders of magnitude between studies. In this short review we aim to explain the reasons for the discrepancies in estimates, clarify which estimates have been superseded and why and highlight the current best estimates. We focus on stable isotope labeling of T cell subsets in healthy humans.
format Online
Article
Text
id pubmed-6941842
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier Ltd
record_format MEDLINE/PubMed
spelling pubmed-69418422020-01-07 Current estimates of T cell kinetics in humans Macallan, Derek C. Busch, Robert Asquith, Becca Curr Opin Syst Biol Article Stable isotope labeling is a generally applicable method of quantifying cell dynamics. Its advent has opened up the way for the quantitative study of T cells in humans. However, the literature is confusing as estimates vary by orders of magnitude between studies. In this short review we aim to explain the reasons for the discrepancies in estimates, clarify which estimates have been superseded and why and highlight the current best estimates. We focus on stable isotope labeling of T cell subsets in healthy humans. Elsevier Ltd 2019-12 /pmc/articles/PMC6941842/ /pubmed/31922055 http://dx.doi.org/10.1016/j.coisb.2019.10.002 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Macallan, Derek C.
Busch, Robert
Asquith, Becca
Current estimates of T cell kinetics in humans
title Current estimates of T cell kinetics in humans
title_full Current estimates of T cell kinetics in humans
title_fullStr Current estimates of T cell kinetics in humans
title_full_unstemmed Current estimates of T cell kinetics in humans
title_short Current estimates of T cell kinetics in humans
title_sort current estimates of t cell kinetics in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941842/
https://www.ncbi.nlm.nih.gov/pubmed/31922055
http://dx.doi.org/10.1016/j.coisb.2019.10.002
work_keys_str_mv AT macallanderekc currentestimatesoftcellkineticsinhumans
AT buschrobert currentestimatesoftcellkineticsinhumans
AT asquithbecca currentestimatesoftcellkineticsinhumans

Ejemplares similares