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Metastatic Phosphatase PRL-3 Induces Ovarian Cancer Stem Cell Sub-population through Phosphatase-Independent Deacetylation Modulations

Cancer stem cells (CSCs) are responsible for tumor initiation, chemoresistance, metastasis, and relapse, but the underlying molecular origin of CSCs remains elusive. Here we identified that metastatic phosphatase of regenerating liver 3 (PRL-3) transcriptionally upregulates SOX2 in the expansion of...

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Detalles Bibliográficos
Autores principales:	Zhang, Mingming, Wei, Yanli, Liu, Yanbin, Guan, Wen, Zhang, Xiaomei, Kong, Jianqiu, Li, Hui, Yang, Shulan, Wang, Haihe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941878/ https://www.ncbi.nlm.nih.gov/pubmed/31887658 http://dx.doi.org/10.1016/j.isci.2019.100766

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