Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1

Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and is associated with a poor prognosis due to frequent distant metastasis and lack of effective targeted therapies. Previously, we identified maternal embryonic leucine zipper kinase (MELK) to be highly expressed in...

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Detalles Bibliográficos
Autores principales: Bollu, Lakshmi Reddy, Shepherd, Jonathan, Zhao, Dekuang, Ma, Yanxia, Tahaney, William, Speers, Corey, Mazumdar, Abhijit, Mills, Gordon B., Brown, Powel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941974/
https://www.ncbi.nlm.nih.gov/pubmed/31909186
http://dx.doi.org/10.1038/s41523-019-0143-5

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