High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1

PURPOSE: The enzymes gamma-glutamyl hydrolase (GGH) and folylpolyglutamate synthetase (FPGS) regulate intracellular folate concentrations needed for cell proliferation, DNA synthesis, and repair. High GGH expression affects 5-FU thymidylate synthase (TS) inhibition and is a risk factor for various m...

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Detalles Bibliográficos
Autores principales: Maezawa, Yukio, Sakamaki, Kentaro, Oue, Naohide, Kimura, Yayoi, Hashimoto, Itaru, Hara, Kentaro, Kano, Kazuki, Aoyama, Toru, Hiroshima, Yukihiko, Yamada, Takanobu, Yamamoto, Naoto, Ogata, Takashi, Ito, Hiroyuki, Cho, Haruhiko, Shiozawa, Manabu, Yoshikawa, Takaki, Morinaga, Soichiro, Rino, Yasushi, Yasui, Wataru, Masuda, Munetaka, Miyagi, Yohei, Oshima, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Article – Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942012/
https://www.ncbi.nlm.nih.gov/pubmed/31754833
http://dx.doi.org/10.1007/s00432-019-03087-8

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