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Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Bromodomain proteins (BRD) are key chromatin regulators of genome function and stability as well as therapeutic targets in cancer. Here, we systematically delineate the contribution of human BRD proteins for genome stability and DNA double-strand break (DSB) repair using several cell-based assays an...

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Detalles Bibliográficos
Autores principales:	Kim, Jae Jin, Lee, Seo Yun, Gong, Fade, Battenhouse, Anna M., Boutz, Daniel R., Bashyal, Aarti, Refvik, Samantha T., Chiang, Cheng-Ming, Xhemalce, Blerta, Paull, Tanya T., Brodbelt, Jennifer S., Marcotte, Edward M., Miller, Kyle M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2019
Materias:	Resource/Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942044/ https://www.ncbi.nlm.nih.gov/pubmed/31753913 http://dx.doi.org/10.1101/gad.331231.119

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