Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat

Knockout of the ubiquitously expressed miRNA-17∼92 cluster in mice produces a lethal developmental lung defect, skeletal abnormalities, and blocked B lymphopoiesis. A shared target of miR-17∼92 miRNAs is the pro-apoptotic protein BIM, central to life-death decisions in mammalian cells. To clarify th...

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Detalles Bibliográficos
Autores principales: Labi, Verena, Peng, Siying, Klironomos, Filippos, Munschauer, Mathias, Kastelic, Nicolai, Chakraborty, Tirtha, Schoeler, Katia, Derudder, Emmanuel, Martella, Manuela, Mastrobuoni, Guido, Hernandez-Miranda, Luis R., Lahmann, Ines, Kocks, Christine, Birchmeier, Carmen, Kempa, Stefan, Quintanilla-Martinez de Fend, Leticia, Landthaler, Markus, Rajewsky, Nikolaus, Rajewsky, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942046/
https://www.ncbi.nlm.nih.gov/pubmed/31699777
http://dx.doi.org/10.1101/gad.330134.119

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