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Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

BACKGROUND: Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM. Systemic delivery of chemotherapeutic drugs is hampered by the difficulty of achieving intratumoral levels as systemic toxicit...

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Detalles Bibliográficos
Autores principales:	Enríquez Pérez, Julio, Kopecky, Jan, Visse, Edward, Darabi, Anna, Siesjö, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942363/ https://www.ncbi.nlm.nih.gov/pubmed/31900109 http://dx.doi.org/10.1186/s12885-019-6502-7

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