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An Unusual Presentation of a Patient with Leg Ulcers: A Case Report
Leg ulcers have been a common presentation in clinics; disruptions in the mechanism of ulcer healing are vascular insufficiency, anemia, metabolic disturbances, neuropathy, and autoimmunity. The term 'non-transfusion-dependent thalassemia' encompasses the milder forms of thalassemia traits...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942503/ https://www.ncbi.nlm.nih.gov/pubmed/31938587 http://dx.doi.org/10.7759/cureus.6293 |
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author | Zafar, Sana Saleem, Khurram Rashid, Aqeela |
author_facet | Zafar, Sana Saleem, Khurram Rashid, Aqeela |
author_sort | Zafar, Sana |
collection | PubMed |
description | Leg ulcers have been a common presentation in clinics; disruptions in the mechanism of ulcer healing are vascular insufficiency, anemia, metabolic disturbances, neuropathy, and autoimmunity. The term 'non-transfusion-dependent thalassemia' encompasses the milder forms of thalassemia traits that require intermittent or no transfusion at all, and are mostly associated with leg ulcers. We present the case of a 19-year-old female with beta-thalassemia major who presented with non-healing leg ulcers and anemia. The clinical findings and lab evidence suggested hemolytic anemia evidenced by pathologic fractures, hepato-splenomegaly, and normal iron studies. Hemoglobin electrophoresis confirmed beta-thalassemia major with its complications including adrenal insufficiency and pathological fractures, all of which remained well compensated till the second decade of life. |
format | Online Article Text |
id | pubmed-6942503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-69425032020-01-14 An Unusual Presentation of a Patient with Leg Ulcers: A Case Report Zafar, Sana Saleem, Khurram Rashid, Aqeela Cureus Hematology Leg ulcers have been a common presentation in clinics; disruptions in the mechanism of ulcer healing are vascular insufficiency, anemia, metabolic disturbances, neuropathy, and autoimmunity. The term 'non-transfusion-dependent thalassemia' encompasses the milder forms of thalassemia traits that require intermittent or no transfusion at all, and are mostly associated with leg ulcers. We present the case of a 19-year-old female with beta-thalassemia major who presented with non-healing leg ulcers and anemia. The clinical findings and lab evidence suggested hemolytic anemia evidenced by pathologic fractures, hepato-splenomegaly, and normal iron studies. Hemoglobin electrophoresis confirmed beta-thalassemia major with its complications including adrenal insufficiency and pathological fractures, all of which remained well compensated till the second decade of life. Cureus 2019-12-05 /pmc/articles/PMC6942503/ /pubmed/31938587 http://dx.doi.org/10.7759/cureus.6293 Text en Copyright © 2019, Zafar et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Hematology Zafar, Sana Saleem, Khurram Rashid, Aqeela An Unusual Presentation of a Patient with Leg Ulcers: A Case Report |
title | An Unusual Presentation of a Patient with Leg Ulcers: A Case Report |
title_full | An Unusual Presentation of a Patient with Leg Ulcers: A Case Report |
title_fullStr | An Unusual Presentation of a Patient with Leg Ulcers: A Case Report |
title_full_unstemmed | An Unusual Presentation of a Patient with Leg Ulcers: A Case Report |
title_short | An Unusual Presentation of a Patient with Leg Ulcers: A Case Report |
title_sort | unusual presentation of a patient with leg ulcers: a case report |
topic | Hematology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942503/ https://www.ncbi.nlm.nih.gov/pubmed/31938587 http://dx.doi.org/10.7759/cureus.6293 |
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