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Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging
Magnetic resonance imaging examinations are frequently carried out using contrast agents to improve the image quality. Practically all clinically used contrast agents are based on paramagnetic metals and lack in selectivity and specificity. A group of stable organic radicals, nitroxides, has raised...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942761/ https://www.ncbi.nlm.nih.gov/pubmed/31920468 http://dx.doi.org/10.1155/2019/5629597 |
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author | Soikkeli, Maiju Kettunen, Mikko I. Nivajärvi, Riikka Olsson, Venla Rönkkö, Seppo Laakkonen, Johanna P. Lehto, Vesa-Pekka Kavakka, Jari Heikkinen, Sami |
author_facet | Soikkeli, Maiju Kettunen, Mikko I. Nivajärvi, Riikka Olsson, Venla Rönkkö, Seppo Laakkonen, Johanna P. Lehto, Vesa-Pekka Kavakka, Jari Heikkinen, Sami |
author_sort | Soikkeli, Maiju |
collection | PubMed |
description | Magnetic resonance imaging examinations are frequently carried out using contrast agents to improve the image quality. Practically all clinically used contrast agents are based on paramagnetic metals and lack in selectivity and specificity. A group of stable organic radicals, nitroxides, has raised interest as new metal-free contrast agents for MRI. Their structures can easily be modified to incorporate different functionalities. In the present study, a stable nitroxide TEEPO (2,2,6,6-tetraethylpiperidin-1-oxyl) was linked to a glucose moiety (Glc) to construct a water-soluble, potentially tumor-targeting compound with contrast-enhancing ability. The ability was assessed with in vivo MRI experiments. The constructed TEEPO-Glc agent proved to shorten the T(1) relaxation time in tumor, while the T(1) time in healthy brain tissue remained the same. The results indicate the potential of TEEPO-Glc as a valuable addition to the growing field of metal-free contrast enhancement in MRI-based diagnostics. |
format | Online Article Text |
id | pubmed-6942761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-69427612020-01-09 Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging Soikkeli, Maiju Kettunen, Mikko I. Nivajärvi, Riikka Olsson, Venla Rönkkö, Seppo Laakkonen, Johanna P. Lehto, Vesa-Pekka Kavakka, Jari Heikkinen, Sami Contrast Media Mol Imaging Research Article Magnetic resonance imaging examinations are frequently carried out using contrast agents to improve the image quality. Practically all clinically used contrast agents are based on paramagnetic metals and lack in selectivity and specificity. A group of stable organic radicals, nitroxides, has raised interest as new metal-free contrast agents for MRI. Their structures can easily be modified to incorporate different functionalities. In the present study, a stable nitroxide TEEPO (2,2,6,6-tetraethylpiperidin-1-oxyl) was linked to a glucose moiety (Glc) to construct a water-soluble, potentially tumor-targeting compound with contrast-enhancing ability. The ability was assessed with in vivo MRI experiments. The constructed TEEPO-Glc agent proved to shorten the T(1) relaxation time in tumor, while the T(1) time in healthy brain tissue remained the same. The results indicate the potential of TEEPO-Glc as a valuable addition to the growing field of metal-free contrast enhancement in MRI-based diagnostics. Hindawi 2019-12-21 /pmc/articles/PMC6942761/ /pubmed/31920468 http://dx.doi.org/10.1155/2019/5629597 Text en Copyright © 2019 Maiju Soikkeli et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Soikkeli, Maiju Kettunen, Mikko I. Nivajärvi, Riikka Olsson, Venla Rönkkö, Seppo Laakkonen, Johanna P. Lehto, Vesa-Pekka Kavakka, Jari Heikkinen, Sami Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging |
title | Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging |
title_full | Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging |
title_fullStr | Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging |
title_full_unstemmed | Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging |
title_short | Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging |
title_sort | assessment of the relaxation-enhancing properties of a nitroxide-based contrast agent teepo-glc with in vivo magnetic resonance imaging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942761/ https://www.ncbi.nlm.nih.gov/pubmed/31920468 http://dx.doi.org/10.1155/2019/5629597 |
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