Cargando…

Hypertension in HIV-Infected Patients Receiving Antiretroviral Therapy in Northeast Ethiopia

BACKGROUND: With prolonged survival and aging of persons with HIV on combination antiretroviral therapy (ART), hypertension has emerged as a significant cause of morbidity and mortality globally. However, little is known about the burden of this comorbid condition among adults living with HIV in sub...

Descripción completa

Detalles Bibliográficos
Autores principales: Fiseha, Temesgen, Belete, Alemu Gedefie, Dereje, Henok, Dires, Abebe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942833/
https://www.ncbi.nlm.nih.gov/pubmed/31929895
http://dx.doi.org/10.1155/2019/4103604
_version_ 1783484780164153344
author Fiseha, Temesgen
Belete, Alemu Gedefie
Dereje, Henok
Dires, Abebe
author_facet Fiseha, Temesgen
Belete, Alemu Gedefie
Dereje, Henok
Dires, Abebe
author_sort Fiseha, Temesgen
collection PubMed
description BACKGROUND: With prolonged survival and aging of persons with HIV on combination antiretroviral therapy (ART), hypertension has emerged as a significant cause of morbidity and mortality globally. However, little is known about the burden of this comorbid condition among adults living with HIV in sub-Saharan Africa. In this study, we aimed to determine the prevalence and factors associated with hypertension among HIV-infected patients receiving ART in Northeast Ethiopia. METHODS: A cross-sectional study was conducted at the ART clinic of Dessie Referral Hospital, Northeast Ethiopia, between January and May 2018. HIV-infected patients who were on ART for at least 12 months were included in the study. Demographic, clinical, and laboratory data were collected from each participant. Hypertension was defined as a systolic blood pressure (BP) of ≥140 mmHg and/or diastolic BP of ≥90 mmHg or a reported use of antihypertensive medication. Univariable and multivariate analyses were performed to identify factors associated with hypertension. RESULTS: A total of 408 patients were studied with a mean (±SD) age of 37 ± 10.3 years, and 66.9% were female. The prevalence of hypertension was 29.7% (95% CI, 25.3–35.0%). Nearly 75% of the patients with hypertension were previously undiagnosed. In a univariate analysis, older age, male gender, a family history of hypertension, duration of HIV infection, duration on ART, high body mass index, low CD4 count, diabetes, and renal impairment were associated with hypertension. Multivariate analysis revealed older age (AOR = 2.08; 95% CI, 1.13–3.83), male gender (AOR = 1.64; 95% CI, 1.01–2.65), longer duration on ART (AOR = 1.91; 95% CI, 1.14–3.20), high body mass index (AOR = 3.32; 95% CI, 1.13–9.77), and diabetes (AOR = 2.76; 95% CI, 1.29–5.89) as independent risk factors of hypertension. CONCLUSIONS: Hypertension is highly prevalent among HIV-infected patients on ART attending our clinic in Northeast Ethiopia but is mostly undiagnosed. These findings highlight the need for integrating hypertension management into routine HIV care to prevent adverse outcomes and improve health of people living with HIV on ART.
format Online
Article
Text
id pubmed-6942833
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-69428332020-01-12 Hypertension in HIV-Infected Patients Receiving Antiretroviral Therapy in Northeast Ethiopia Fiseha, Temesgen Belete, Alemu Gedefie Dereje, Henok Dires, Abebe Int J Hypertens Research Article BACKGROUND: With prolonged survival and aging of persons with HIV on combination antiretroviral therapy (ART), hypertension has emerged as a significant cause of morbidity and mortality globally. However, little is known about the burden of this comorbid condition among adults living with HIV in sub-Saharan Africa. In this study, we aimed to determine the prevalence and factors associated with hypertension among HIV-infected patients receiving ART in Northeast Ethiopia. METHODS: A cross-sectional study was conducted at the ART clinic of Dessie Referral Hospital, Northeast Ethiopia, between January and May 2018. HIV-infected patients who were on ART for at least 12 months were included in the study. Demographic, clinical, and laboratory data were collected from each participant. Hypertension was defined as a systolic blood pressure (BP) of ≥140 mmHg and/or diastolic BP of ≥90 mmHg or a reported use of antihypertensive medication. Univariable and multivariate analyses were performed to identify factors associated with hypertension. RESULTS: A total of 408 patients were studied with a mean (±SD) age of 37 ± 10.3 years, and 66.9% were female. The prevalence of hypertension was 29.7% (95% CI, 25.3–35.0%). Nearly 75% of the patients with hypertension were previously undiagnosed. In a univariate analysis, older age, male gender, a family history of hypertension, duration of HIV infection, duration on ART, high body mass index, low CD4 count, diabetes, and renal impairment were associated with hypertension. Multivariate analysis revealed older age (AOR = 2.08; 95% CI, 1.13–3.83), male gender (AOR = 1.64; 95% CI, 1.01–2.65), longer duration on ART (AOR = 1.91; 95% CI, 1.14–3.20), high body mass index (AOR = 3.32; 95% CI, 1.13–9.77), and diabetes (AOR = 2.76; 95% CI, 1.29–5.89) as independent risk factors of hypertension. CONCLUSIONS: Hypertension is highly prevalent among HIV-infected patients on ART attending our clinic in Northeast Ethiopia but is mostly undiagnosed. These findings highlight the need for integrating hypertension management into routine HIV care to prevent adverse outcomes and improve health of people living with HIV on ART. Hindawi 2019-12-23 /pmc/articles/PMC6942833/ /pubmed/31929895 http://dx.doi.org/10.1155/2019/4103604 Text en Copyright © 2019 Temesgen Fiseha et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fiseha, Temesgen
Belete, Alemu Gedefie
Dereje, Henok
Dires, Abebe
Hypertension in HIV-Infected Patients Receiving Antiretroviral Therapy in Northeast Ethiopia
title Hypertension in HIV-Infected Patients Receiving Antiretroviral Therapy in Northeast Ethiopia
title_full Hypertension in HIV-Infected Patients Receiving Antiretroviral Therapy in Northeast Ethiopia
title_fullStr Hypertension in HIV-Infected Patients Receiving Antiretroviral Therapy in Northeast Ethiopia
title_full_unstemmed Hypertension in HIV-Infected Patients Receiving Antiretroviral Therapy in Northeast Ethiopia
title_short Hypertension in HIV-Infected Patients Receiving Antiretroviral Therapy in Northeast Ethiopia
title_sort hypertension in hiv-infected patients receiving antiretroviral therapy in northeast ethiopia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942833/
https://www.ncbi.nlm.nih.gov/pubmed/31929895
http://dx.doi.org/10.1155/2019/4103604
work_keys_str_mv AT fisehatemesgen hypertensioninhivinfectedpatientsreceivingantiretroviraltherapyinnortheastethiopia
AT beletealemugedefie hypertensioninhivinfectedpatientsreceivingantiretroviraltherapyinnortheastethiopia
AT derejehenok hypertensioninhivinfectedpatientsreceivingantiretroviraltherapyinnortheastethiopia
AT diresabebe hypertensioninhivinfectedpatientsreceivingantiretroviraltherapyinnortheastethiopia