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Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years

BACKGROUND: The trends in pediatric patients having thyroid nodules have not been well evaluated. Here, we analyzed the clinicopathological features of the children who have presented with thyroid nodules at our center over several decades in order to determine a change of trend. MATERIALS AND METHO...

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Autores principales: Rah, Cheong-Sil, Kim, Won Woong, Lee, Yu-mi, Kim, Won Gu, Song, Dong Eun, Chung, Ki-Wook, Kim, Seong Chul, Hong, Suck Joon, Sung, Tae-Yon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942841/
https://www.ncbi.nlm.nih.gov/pubmed/31933637
http://dx.doi.org/10.1155/2019/1829043
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author Rah, Cheong-Sil
Kim, Won Woong
Lee, Yu-mi
Kim, Won Gu
Song, Dong Eun
Chung, Ki-Wook
Kim, Seong Chul
Hong, Suck Joon
Sung, Tae-Yon
author_facet Rah, Cheong-Sil
Kim, Won Woong
Lee, Yu-mi
Kim, Won Gu
Song, Dong Eun
Chung, Ki-Wook
Kim, Seong Chul
Hong, Suck Joon
Sung, Tae-Yon
author_sort Rah, Cheong-Sil
collection PubMed
description BACKGROUND: The trends in pediatric patients having thyroid nodules have not been well evaluated. Here, we analyzed the clinicopathological features of the children who have presented with thyroid nodules at our center over several decades in order to determine a change of trend. MATERIALS AND METHODS: We analyzed 215 pediatric patients who had undergone a thyroidectomy between 1990 and 2014 at our single tertiary center. The clinicopathological features were analyzed according to age, sex, and the year of diagnosis. RESULTS: The most common reason for hospital admission was a palpable anterior neck mass (76.7%). The males in the patient cohort were younger than the females (13 vs. 15 years old, p < 0.05). The female patients increased from 50.0% to 83.0% with age (p < 0.05). The rate of malignancy did not increase with age (p < 0.05). However, the malignancy rate was higher in the more recently seen patients (23.8% during the early study period and 86.8% in the late study period; p < 0.05). CONCLUSION: Following a thyroidectomy in children with thyroid nodules, there was no change in the rate of detection of thyroid cancer over time with age, although the detected frequency of malignancy has increased in more recent patients. Therefore, early thyroid nodule detection for malignant screening is likely to be required for pediatric patients in the near future.
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spelling pubmed-69428412020-01-13 Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years Rah, Cheong-Sil Kim, Won Woong Lee, Yu-mi Kim, Won Gu Song, Dong Eun Chung, Ki-Wook Kim, Seong Chul Hong, Suck Joon Sung, Tae-Yon Int J Endocrinol Research Article BACKGROUND: The trends in pediatric patients having thyroid nodules have not been well evaluated. Here, we analyzed the clinicopathological features of the children who have presented with thyroid nodules at our center over several decades in order to determine a change of trend. MATERIALS AND METHODS: We analyzed 215 pediatric patients who had undergone a thyroidectomy between 1990 and 2014 at our single tertiary center. The clinicopathological features were analyzed according to age, sex, and the year of diagnosis. RESULTS: The most common reason for hospital admission was a palpable anterior neck mass (76.7%). The males in the patient cohort were younger than the females (13 vs. 15 years old, p < 0.05). The female patients increased from 50.0% to 83.0% with age (p < 0.05). The rate of malignancy did not increase with age (p < 0.05). However, the malignancy rate was higher in the more recently seen patients (23.8% during the early study period and 86.8% in the late study period; p < 0.05). CONCLUSION: Following a thyroidectomy in children with thyroid nodules, there was no change in the rate of detection of thyroid cancer over time with age, although the detected frequency of malignancy has increased in more recent patients. Therefore, early thyroid nodule detection for malignant screening is likely to be required for pediatric patients in the near future. Hindawi 2019-12-20 /pmc/articles/PMC6942841/ /pubmed/31933637 http://dx.doi.org/10.1155/2019/1829043 Text en Copyright © 2019 Cheong-Sil Rah et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rah, Cheong-Sil
Kim, Won Woong
Lee, Yu-mi
Kim, Won Gu
Song, Dong Eun
Chung, Ki-Wook
Kim, Seong Chul
Hong, Suck Joon
Sung, Tae-Yon
Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years
title Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years
title_full Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years
title_fullStr Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years
title_full_unstemmed Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years
title_short Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years
title_sort recent trends in the clinicopathological features of thyroid nodules in pediatric patients: a single tertiary center experience over 25 years
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942841/
https://www.ncbi.nlm.nih.gov/pubmed/31933637
http://dx.doi.org/10.1155/2019/1829043
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