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Targeted delivery and enhanced gene-silencing activity of centrally modified folic acid–siRNA conjugates
One of the major hurdles in RNAi research has been the development of safe and effective delivery systems for siRNAs. Although various chemical modifications have been proposed to improve their pharmacokinetic behaviour, their delivery to target cells and tissues presents many challenges. In this wo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943128/ https://www.ncbi.nlm.nih.gov/pubmed/31777918 http://dx.doi.org/10.1093/nar/gkz1115 |