In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3′ and 5′ thiophosphate linkages

The introduction of non-bridging phosphorothioate (PS) linkages in oligonucleotides has been instrumental for the development of RNA therapeutics and antisense oligonucleotides. This modification offers significantly increased metabolic stability as well as improved pharmacokinetic properties. Howev...

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Detalles Bibliográficos
Autores principales: Duschmalé, Jörg, Hansen, Henrik Frydenlund, Duschmalé, Martina, Koller, Erich, Albaek, Nanna, Møller, Marianne Ravn, Jensen, Klaus, Koch, Troels, Wengel, Jesper, Bleicher, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943131/
https://www.ncbi.nlm.nih.gov/pubmed/31754711
http://dx.doi.org/10.1093/nar/gkz1099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943131/
https://www.ncbi.nlm.nih.gov/pubmed/31754711
http://dx.doi.org/10.1093/nar/gkz1099

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