Cargando…

Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites

DNA cytosine modifications are key epigenetic regulators of cellular processes in mammalian cells, with their misregulation leading to varied disease states. In the human malaria parasite Plasmodium falciparum, a unicellular eukaryotic pathogen, little is known about the predominant cytosine modific...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hammam, Elie, Ananda, Guruprasad, Sinha, Ameya, Scheidig-Benatar, Christine, Bohec, Mylene, Preiser, Peter R, Dedon, Peter C, Scherf, Artur, Vembar, Shruthi S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943133/ https://www.ncbi.nlm.nih.gov/pubmed/31777939 http://dx.doi.org/10.1093/nar/gkz1093

Ejemplares similares

Cytosine methylation alters DNA mechanical properties
por: Severin, Philip M. D., et al.
Publicado: (2011)

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
por: Hashimoto, Hideharu, et al.
Publicado: (2012)

N(4)-cytosine DNA methylation regulates transcription and pathogenesis in Helicobacter pylori
por: Kumar, Sumith, et al.
Publicado: (2018)

APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA
por: Schutsky, Emily K., et al.
Publicado: (2017)

Trans-acting GC-rich non-coding RNA at var expression site modulates gene counting in malaria parasite
por: Guizetti, Julien, et al.
Publicado: (2016)

Cytosine methylation at CpCpG sites triggers accumulation of non-CpG methylation in gene bodies
por: Zabet, Nicolae Radu, et al.
Publicado: (2017)

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers
por: Oda, Mayumi, et al.
Publicado: (2009)

Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes
por: Pérez-Toledo, Karla, et al.
Publicado: (2009)

Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation
por: Hammam, Elie, et al.
Publicado: (2021)

The histone variant H2A.Z is an important regulator of enhancer activity
por: Brunelle, Mylène, et al.
Publicado: (2015)

Heat shock factor 1 promotes TERRA transcription and telomere protection upon heat stress
por: Koskas, Sivan, et al.
Publicado: (2017)

Species-specific recruitment of transcription factors dictates toxin expression
por: Trouillon, Julian, et al.
Publicado: (2020)

Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA context
por: Le Noir, Sandrine, et al.
Publicado: (2017)

The Burkholderia cenocepacia iron starvation σ factor, OrbS, possesses an on-board iron sensor
por: Butt, Aaron T, et al.
Publicado: (2022)

Translational co-regulation of a ligand and inhibitor by a conserved RNA element
por: Zaucker, Andreas, et al.
Publicado: (2018)

The SR-protein Npl3 is an essential component of the meiotic splicing regulatory network in Saccharomyces cerevisiae
por: Sandhu, Rima, et al.
Publicado: (2021)

Integrating motif, DNA accessibility and gene expression data to build regulatory maps in an organism
por: Blatti, Charles, et al.
Publicado: (2015)

Evolutionary re-wiring of p63 and the epigenomic regulatory landscape in keratinocytes and its potential implications on species-specific gene expression and phenotypes
por: Sethi, Isha, et al.
Publicado: (2017)

Histone H3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms
por: Chatterjee, Nilanjana, et al.
Publicado: (2011)

Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons
por: Szafranski, Karol, et al.
Publicado: (2014)

USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation
por: Draker, Ryan, et al.
Publicado: (2011)

Interaction with ZMYND11 mediates opposing roles of Ras-responsive transcription factors ETS1 and ETS2
por: Plotnik, Joshua P., et al.
Publicado: (2017)

Native elongation transcript sequencing reveals temperature dependent dynamics of nascent RNAPII transcription in Arabidopsis
por: Kindgren, Peter, et al.
Publicado: (2020)

Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes
por: Schreiner, Sabrina, et al.
Publicado: (2013)

A critical role for linker DNA in higher-order folding of chromatin fibers
por: Brouwer, Thomas, et al.
Publicado: (2021)

Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival
por: Noy, Peter, et al.
Publicado: (2012)

Effects of DNA methylation on nucleosome stability
por: Collings, Clayton K., et al.
Publicado: (2013)

Specificity of MYB interactions relies on motifs in ordered and disordered contexts
por: Millard, Peter S, et al.
Publicado: (2019)

Genetic context effects can override canonical cis regulatory elements in Escherichia coli
por: Scholz, Scott A, et al.
Publicado: (2022)

FUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNPs and histone-specific transcription factors
por: Raczynska, Katarzyna Dorota, et al.
Publicado: (2015)

Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell-cycle-associated target gene promoters
por: Barros, Patrícia, et al.
Publicado: (2012)

Space exploration by the promoter of a long human gene during one transcription cycle
por: Larkin, Joshua D., et al.
Publicado: (2013)

Widespread repression of anti-CRISPR production by anti-CRISPR-associated proteins
por: Shehreen, Saadlee, et al.
Publicado: (2022)

Analysis of individual remodeled nucleosomes reveals decreased histone–DNA contacts created by hSWI/SNF
por: Bouazoune, Karim, et al.
Publicado: (2009)

Hydroxymethyluracil modifications enhance the flexibility and hydrophilicity of double-stranded DNA
por: Carson, Spencer, et al.
Publicado: (2016)

The ISW1 and CHD1 ATP-dependent chromatin remodelers compete to set nucleosome spacing in vivo
por: Ocampo, Josefina, et al.
Publicado: (2016)

Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif
por: Ramakrishnan, Aravinda-Bharathi, et al.
Publicado: (2021)

A mobile restriction–modification system provides phage defence and resolves an epigenetic conflict with an antagonistic endonuclease
por: Birkholz, Nils, et al.
Publicado: (2022)

Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells
por: Hawkins, Peter G., et al.
Publicado: (2009)

The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome
por: Fauth, Torsten, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_78a8qsr43sep6cfquscrjl0mvr