SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21(CIPI), cyclin D1 and β‐catenin

The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and...

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Autores principales: Lv, Liyan, Zhou, Min, Zhang, Jian, Liu, Fang, Qi, Li, Zhang, Shuai, Bi, Yi, Yu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943225/
https://www.ncbi.nlm.nih.gov/pubmed/31729835
http://dx.doi.org/10.1002/2211-5463.12762
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author Lv, Liyan
Zhou, Min
Zhang, Jian
Liu, Fang
Qi, Li
Zhang, Shuai
Bi, Yi
Yu, Yan
author_facet Lv, Liyan
Zhou, Min
Zhang, Jian
Liu, Fang
Qi, Li
Zhang, Shuai
Bi, Yi
Yu, Yan
author_sort Lv, Liyan
collection PubMed
description The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21(CIPI) and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma.
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spelling pubmed-69432252020-01-07 SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21(CIPI), cyclin D1 and β‐catenin Lv, Liyan Zhou, Min Zhang, Jian Liu, Fang Qi, Li Zhang, Shuai Bi, Yi Yu, Yan FEBS Open Bio Research Articles The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21(CIPI) and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma. John Wiley and Sons Inc. 2019-12-12 /pmc/articles/PMC6943225/ /pubmed/31729835 http://dx.doi.org/10.1002/2211-5463.12762 Text en © 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Lv, Liyan
Zhou, Min
Zhang, Jian
Liu, Fang
Qi, Li
Zhang, Shuai
Bi, Yi
Yu, Yan
SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21(CIPI), cyclin D1 and β‐catenin
title SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21(CIPI), cyclin D1 and β‐catenin
title_full SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21(CIPI), cyclin D1 and β‐catenin
title_fullStr SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21(CIPI), cyclin D1 and β‐catenin
title_full_unstemmed SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21(CIPI), cyclin D1 and β‐catenin
title_short SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21(CIPI), cyclin D1 and β‐catenin
title_sort sox6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21(cipi), cyclin d1 and β‐catenin
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943225/
https://www.ncbi.nlm.nih.gov/pubmed/31729835
http://dx.doi.org/10.1002/2211-5463.12762
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