Cargando…

Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome

BACKGROUND: The hypoglycemic drugs dipeptidyl peptidase-4 (DPP-4) inhibitors have proven protective effects on diabetic kidney disease, including renal fibrosis. Although NOD-like receptor protein 3 (NLRP3) inflammasome activation is known to play an important role in the progression of renal fibros...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seo, Jung Beom, Choi, Yeon-Kyung, Woo, Hye-In, Jung, Yun-A, Lee, Sungwoo, Lee, Seunghyeong, Park, Mihyang, Lee, In-Kyu, Jung, Gwon-Soo, Park, Keun-Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Diabetes Association 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943262/ https://www.ncbi.nlm.nih.gov/pubmed/30877711 http://dx.doi.org/10.4093/dmj.2018.0181

Ejemplares similares

Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
por: Kim, Mi-Jin, et al.
Publicado: (2020)

Melatonin inhibits vascular smooth muscle cell proliferation and apoptosis through upregulation of Sestrin2
por: Lee, Seunghyeong, et al.
Publicado: (2020)

Renoprotective Effect of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, in Streptozotocin-Induced Type 1 Diabetic Mice
por: Jung, Gwon-Soo, et al.
Publicado: (2016)

Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
por: Bae, Kwi-Hyun, et al.
Publicado: (2017)

Inhibitory Effect of a Glutamine Antagonist on Proliferation and Migration of VSMCs via Simultaneous Attenuation of Glycolysis and Oxidative Phosphorylation
por: Park, Hyeon Young, et al.
Publicado: (2021)

Gemigliptin: An Update of Its Clinical Use in the Management of Type 2 Diabetes Mellitus
por: Kim, Sung-Ho, et al.
Publicado: (2016)

Clusterin/Apolipoprotein J Attenuates Angiotensin II-Induced Renal Fibrosis
por: Jung, Gwon-Soo, et al.
Publicado: (2014)

Contribution of Autophagy-Notch1-Mediated NLRP3 Inflammasome Activation to Chronic Inflammation and Fibrosis in Keloid Fibroblasts
por: Lee, Seongju, et al.
Publicado: (2020)

Activation of NLRP3 Inflammasome by Palmitic Acid in Human Sebocytes
por: Jung, Yu-Ra, et al.
Publicado: (2021)

Psoralen Alleviates Renal Fibrosis by Attenuating Inflammasome-Dependent NLRP3 Activation and Epithelial–Mesenchymal Transition in a Mouse Unilateral Ureteral Obstruction Model
por: Lee, Tae Won, et al.
Publicado: (2023)

Lobeglitazone inhibits LPS-induced NLRP3 inflammasome activation and inflammation in the liver
por: Seo, Hye-Young, et al.
Publicado: (2023)

The Role of the NLRP3 Inflammasome in Fibrosis
por: Artlett, Carol M
Publicado: (2012)

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome
por: Yang, Chul-Su, et al.
Publicado: (2015)

Spirulina maxima extract prevents activation of the NLRP3 inflammasome by inhibiting ERK signaling
por: Chei, Sungwoo, et al.
Publicado: (2020)

Effect of gemigliptin on cardiac ischemia/reperfusion and spontaneous hypertensive rat models
por: Nam, Dae-Hwan, et al.
Publicado: (2019)

Ameliorating Effect of Gemigliptin on Renal Injury in Murine Adriamycin-Induced Nephropathy
por: Kim, Da Rae, et al.
Publicado: (2017)

Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome
por: Bae, Kwi-Hyun, et al.
Publicado: (2018)

Protective Effects of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, against Cisplatin-Induced Nephrotoxicity in Mice
por: Choi, Seung Hee, et al.
Publicado: (2017)

Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases
por: Seok, Jin Kyung, et al.
Publicado: (2021)

TLR2 and the NLRP3 inflammasome mediate IL-1β production in Prevotella nigrescens-infected dendritic cells
por: Jang, Hye-Mi, et al.
Publicado: (2021)

Unveiling the Crucial Role of Type IV Secretion System and Motility of Helicobacter pylori in IL-1β Production via NLRP3 Inflammasome Activation in Neutrophils
por: Jang, Ah-Ra, et al.
Publicado: (2020)

Acute Glucose Shift Induces the Activation of the NLRP3 Inflammasome in THP-1 Cells
por: Lee, Ji Yeon, et al.
Publicado: (2021)

Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity
por: Lee, Seunghyeong, et al.
Publicado: (2022)

Pharmacokinetic Equivalence of the High Dose Strength Fixed-Dose Combination Tablet of Gemigliptin/Metformin Sustained Release (SR) and Individual Component Gemigliptin and Metformin XR Tablets in Healthy Subjects
por: Cho, Yong-Soon, et al.
Publicado: (2018)

Defective mitochondrial fission augments NLRP3 inflammasome activation
por: Park, Sangjun, et al.
Publicado: (2015)

MicroRNA-132 Negatively Regulates Palmitate-Induced NLRP3 Inflammasome Activation through FOXO3 Down-Regulation in THP-1 Cells
por: Byeon, Hye-Eun, et al.
Publicado: (2017)

Regulation of the NLRP3 Inflammasome by Post-Translational Modifications and Small Molecules
por: Seok, Jin Kyung, et al.
Publicado: (2021)

Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis
por: Lee, Hye Eun, et al.
Publicado: (2019)

Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout
por: Lee, Hye Eun, et al.
Publicado: (2016)

PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis
por: Nam, Bo Young, et al.
Publicado: (2022)

Sinapic Acid Controls Inflammation by Suppressing NLRP3 Inflammasome Activation
por: Lee, Eun Hye, et al.
Publicado: (2021)

Korean Red Ginseng, a regulator of NLRP3 inflammasome, in the COVID-19 pandemic
por: Jung, Eui-Man, et al.
Publicado: (2022)

Ethanol extract of Chrysanthemum zawadskii inhibits the NLRP3 inflammasome by suppressing ASC oligomerization in macrophages
por: Jang, Ah-Ra, et al.
Publicado: (2023)

NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation
por: Ahn, Huijeong, et al.
Publicado: (2021)

A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects
por: Park, Sang-In, et al.
Publicado: (2015)

Loganin Prevents Hepatic Steatosis by Blocking NLRP3 Inflammasome Activation
por: Jang, Joo Hyeon, et al.
Publicado: (2023)

The Role of Autophagy and NLRP3 Inflammasome in Liver Fibrosis
por: Tao, Ye, et al.
Publicado: (2020)

The Mechanism and Regulation of the NLRP3 Inflammasome during Fibrosis
por: Artlett, Carol M.
Publicado: (2022)

Ethanol Augments Monosodium Urate-Induced NLRP3 Inflammasome Activation via Regulation of AhR and TXNIP in Human Macrophages
por: Kim, Seong-Kyu, et al.
Publicado: (2020)

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway
por: Nam, Sun Ah, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8alj6fpd95qik8j5ok4it3hvpm