In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval

Correction formulae of QT interval were developed for the halothane-anesthetized microminipigs by adopting atrial pacing (n=5), which were compared with Bazett’s and Fridericia’s formulae for humans, and Van de Water’s one for dogs. The correction formulae: QTc=QT−0.2072 (RR−750) as linear and QTc=Q...

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Autores principales: KAMBAYASHI, Ryuichi, HAGIWARA-NAGASAWA, Mihoko, GOTO, Ai, CHIBA, Koki, IZUMI-NAKASEKO, Hiroko, NAITO, Atsuhiko T., MATSUMOTO, Akio, SUGIYAMA, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Laboratory Animal Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943312/
https://www.ncbi.nlm.nih.gov/pubmed/31611491
http://dx.doi.org/10.1292/jvms.19-0252
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author KAMBAYASHI, Ryuichi
HAGIWARA-NAGASAWA, Mihoko
GOTO, Ai
CHIBA, Koki
IZUMI-NAKASEKO, Hiroko
NAITO, Atsuhiko T.
MATSUMOTO, Akio
SUGIYAMA, Atsushi
author_facet KAMBAYASHI, Ryuichi
HAGIWARA-NAGASAWA, Mihoko
GOTO, Ai
CHIBA, Koki
IZUMI-NAKASEKO, Hiroko
NAITO, Atsuhiko T.
MATSUMOTO, Akio
SUGIYAMA, Atsushi
author_sort KAMBAYASHI, Ryuichi
collection PubMed
description Correction formulae of QT interval were developed for the halothane-anesthetized microminipigs by adopting atrial pacing (n=5), which were compared with Bazett’s and Fridericia’s formulae for humans, and Van de Water’s one for dogs. The correction formulae: QTc=QT−0.2072 (RR−750) as linear and QTc=QT/(RR/750)(0.4007) as non-linear equations, were developed for microminipigs. These formulae can better correct the QT interval of the microminipigs compared with each of the conventional ones for humans and dogs. Moreover, analysis of the slope constant α values indicates that the rate-dependent change in the ventricular repolarization period of microminipig may better mimic that of humans than that of dogs.
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spelling pubmed-69433122020-01-08 In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval KAMBAYASHI, Ryuichi HAGIWARA-NAGASAWA, Mihoko GOTO, Ai CHIBA, Koki IZUMI-NAKASEKO, Hiroko NAITO, Atsuhiko T. MATSUMOTO, Akio SUGIYAMA, Atsushi J Vet Med Sci Laboratory Animal Science Correction formulae of QT interval were developed for the halothane-anesthetized microminipigs by adopting atrial pacing (n=5), which were compared with Bazett’s and Fridericia’s formulae for humans, and Van de Water’s one for dogs. The correction formulae: QTc=QT−0.2072 (RR−750) as linear and QTc=QT/(RR/750)(0.4007) as non-linear equations, were developed for microminipigs. These formulae can better correct the QT interval of the microminipigs compared with each of the conventional ones for humans and dogs. Moreover, analysis of the slope constant α values indicates that the rate-dependent change in the ventricular repolarization period of microminipig may better mimic that of humans than that of dogs. The Japanese Society of Veterinary Science 2019-10-14 2019-12 /pmc/articles/PMC6943312/ /pubmed/31611491 http://dx.doi.org/10.1292/jvms.19-0252 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Laboratory Animal Science
KAMBAYASHI, Ryuichi
HAGIWARA-NAGASAWA, Mihoko
GOTO, Ai
CHIBA, Koki
IZUMI-NAKASEKO, Hiroko
NAITO, Atsuhiko T.
MATSUMOTO, Akio
SUGIYAMA, Atsushi
In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval
title In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval
title_full In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval
title_fullStr In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval
title_full_unstemmed In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval
title_short In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval
title_sort in vivo characterization of rate-dependent impact on the qt interval of microminipig assessed by atrial electrical pacing: development of correction formulae of qt interval
topic Laboratory Animal Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943312/
https://www.ncbi.nlm.nih.gov/pubmed/31611491
http://dx.doi.org/10.1292/jvms.19-0252
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