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Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing’s disease

An 18-year-old male Yorkshire Terrier was admitted with a history of neurological signs including dullness and progressive tetraparesis. Physical examination revealed bilaterally symmetrical alopecia and pot-bellied abdomen. Computed tomography and necropsy examination showed a mass across the front...

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Autores principales: BAEK, Yeong-Bin, ANG, Mary Jasmin, PARK, Jun-Gyu, YU, DoHyeon, PARK, Seungjo, LEE, Jae-Hyuk, CHOI, Jihye, CHO, Kyoung-Oh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943326/
https://www.ncbi.nlm.nih.gov/pubmed/31656239
http://dx.doi.org/10.1292/jvms.19-0386
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author BAEK, Yeong-Bin
ANG, Mary Jasmin
PARK, Jun-Gyu
YU, DoHyeon
PARK, Seungjo
LEE, Jae-Hyuk
CHOI, Jihye
CHO, Kyoung-Oh
author_facet BAEK, Yeong-Bin
ANG, Mary Jasmin
PARK, Jun-Gyu
YU, DoHyeon
PARK, Seungjo
LEE, Jae-Hyuk
CHOI, Jihye
CHO, Kyoung-Oh
author_sort BAEK, Yeong-Bin
collection PubMed
description An 18-year-old male Yorkshire Terrier was admitted with a history of neurological signs including dullness and progressive tetraparesis. Physical examination revealed bilaterally symmetrical alopecia and pot-bellied abdomen. Computed tomography and necropsy examination showed a mass across the frontal sinus and cerebral frontal lobe, bilateral adrenocortical hyperplasia, and hepatomegaly. Histopathologically, the tumor lesions consisted of sheets, nests, or cords of small- to medium-sized round-to-polyhedral cells. Adrenal cortex showed bilateral diffuse cellular proliferation, and some hepatocytes showed intracytoplasmic glycogen accumulation. Immunohistochemically, the tumor cells were positive for pancytokeratin, chromogranin-A, neuron-specific enolase, S100, synaptophysin, and thyroid transcription factor-1 but negative for microtubule-associated proein-2 and neurofilament, leading to the diagnosis of neuroendocrine tumor. These tumor cells were also positive for adrenocorticotropic hormone.
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spelling pubmed-69433262020-01-08 Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing’s disease BAEK, Yeong-Bin ANG, Mary Jasmin PARK, Jun-Gyu YU, DoHyeon PARK, Seungjo LEE, Jae-Hyuk CHOI, Jihye CHO, Kyoung-Oh J Vet Med Sci Pathology An 18-year-old male Yorkshire Terrier was admitted with a history of neurological signs including dullness and progressive tetraparesis. Physical examination revealed bilaterally symmetrical alopecia and pot-bellied abdomen. Computed tomography and necropsy examination showed a mass across the frontal sinus and cerebral frontal lobe, bilateral adrenocortical hyperplasia, and hepatomegaly. Histopathologically, the tumor lesions consisted of sheets, nests, or cords of small- to medium-sized round-to-polyhedral cells. Adrenal cortex showed bilateral diffuse cellular proliferation, and some hepatocytes showed intracytoplasmic glycogen accumulation. Immunohistochemically, the tumor cells were positive for pancytokeratin, chromogranin-A, neuron-specific enolase, S100, synaptophysin, and thyroid transcription factor-1 but negative for microtubule-associated proein-2 and neurofilament, leading to the diagnosis of neuroendocrine tumor. These tumor cells were also positive for adrenocorticotropic hormone. The Japanese Society of Veterinary Science 2019-10-28 2019-12 /pmc/articles/PMC6943326/ /pubmed/31656239 http://dx.doi.org/10.1292/jvms.19-0386 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
BAEK, Yeong-Bin
ANG, Mary Jasmin
PARK, Jun-Gyu
YU, DoHyeon
PARK, Seungjo
LEE, Jae-Hyuk
CHOI, Jihye
CHO, Kyoung-Oh
Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing’s disease
title Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing’s disease
title_full Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing’s disease
title_fullStr Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing’s disease
title_full_unstemmed Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing’s disease
title_short Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing’s disease
title_sort canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with cushing’s disease
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943326/
https://www.ncbi.nlm.nih.gov/pubmed/31656239
http://dx.doi.org/10.1292/jvms.19-0386
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