A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds

Highly functionalized furans are the key scaffolds of many pharmaceuticals and bioactive natural products. Herein, we disclose a new fruitful synthesis of polyfunctionalized furans starting from β-nitroenones and α-functionalized ketones. The protocol involves two steps promoted by solid supported s...

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Detalles Bibliográficos
Autores principales: Chiurchiù, Elena, Gabrielli, Serena, Ballini, Roberto, Palmieri, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943492/
https://www.ncbi.nlm.nih.gov/pubmed/31847286
http://dx.doi.org/10.3390/molecules24244575
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author Chiurchiù, Elena
Gabrielli, Serena
Ballini, Roberto
Palmieri, Alessandro
author_facet Chiurchiù, Elena
Gabrielli, Serena
Ballini, Roberto
Palmieri, Alessandro
author_sort Chiurchiù, Elena
collection PubMed
description Highly functionalized furans are the key scaffolds of many pharmaceuticals and bioactive natural products. Herein, we disclose a new fruitful synthesis of polyfunctionalized furans starting from β-nitroenones and α-functionalized ketones. The protocol involves two steps promoted by solid supported species, and it provides the title targets from satisfactory to very good overall yields and in an excellent diastereomeric ratios.
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spelling pubmed-69434922020-01-10 A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds Chiurchiù, Elena Gabrielli, Serena Ballini, Roberto Palmieri, Alessandro Molecules Article Highly functionalized furans are the key scaffolds of many pharmaceuticals and bioactive natural products. Herein, we disclose a new fruitful synthesis of polyfunctionalized furans starting from β-nitroenones and α-functionalized ketones. The protocol involves two steps promoted by solid supported species, and it provides the title targets from satisfactory to very good overall yields and in an excellent diastereomeric ratios. MDPI 2019-12-13 /pmc/articles/PMC6943492/ /pubmed/31847286 http://dx.doi.org/10.3390/molecules24244575 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chiurchiù, Elena
Gabrielli, Serena
Ballini, Roberto
Palmieri, Alessandro
A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds
title A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds
title_full A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds
title_fullStr A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds
title_full_unstemmed A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds
title_short A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds
title_sort new valuable synthesis of polyfunctionalized furans starting from β-nitroenones and active methylene compounds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943492/
https://www.ncbi.nlm.nih.gov/pubmed/31847286
http://dx.doi.org/10.3390/molecules24244575
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