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Preparative Method for Asymmetric Synthesis of (S)-2-Amino-4,4,4-trifluorobutanoic Acid

Enantiomerically pure derivatives of 2-amino-4,4,4-trifluorobutanoic acid are in great demand as bioisostere of leucine moiety in the drug design. Here, we disclose a method specifically developed for large-scale (>150 g) preparation of the target (S)-N-Fmoc-2-amino-4,4,4-trifluorobutanoic acid....

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Detalles Bibliográficos
Autores principales:	Han, Jianlin, Takeda, Ryosuke, Liu, Xinyi, Konno, Hiroyuki, Abe, Hidenori, Hiramatsu, Takahiro, Moriwaki, Hiroki, Soloshonok, Vadim A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943542/ https://www.ncbi.nlm.nih.gov/pubmed/31835583 http://dx.doi.org/10.3390/molecules24244521

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