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Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers
Heparinoid is the generic term that is used for heparin, heparan sulfate (HS), and heparin-like molecules of animal or plant origin and synthetic derivatives of sulfated polysaccharides. Various biological activities of heparin/HS are attributed to their specific interaction and regulation with vari...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943580/ https://www.ncbi.nlm.nih.gov/pubmed/31861225 http://dx.doi.org/10.3390/molecules24244630 |
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author | Ishihara, Masayuki Nakamura, Shingo Sato, Yoko Takayama, Tomohiro Fukuda, Koichi Fujita, Masanori Murakami, Kaoru Yokoe, Hidetaka |
author_facet | Ishihara, Masayuki Nakamura, Shingo Sato, Yoko Takayama, Tomohiro Fukuda, Koichi Fujita, Masanori Murakami, Kaoru Yokoe, Hidetaka |
author_sort | Ishihara, Masayuki |
collection | PubMed |
description | Heparinoid is the generic term that is used for heparin, heparan sulfate (HS), and heparin-like molecules of animal or plant origin and synthetic derivatives of sulfated polysaccharides. Various biological activities of heparin/HS are attributed to their specific interaction and regulation with various heparin-binding cytokines, antithrombin (AT), and extracellular matrix (ECM) biomolecules. Specific domains with distinct saccharide sequences in heparin/HS mediate these interactions are mediated and require different highly sulfated saccharide sequences with different combinations of sulfated groups. Multivalent and cluster effects of the specific sulfated sequences in heparinoids are also important factors that control their interactions and biological activities. This review provides an overview of heparinoid-based biomaterials that offer novel means of engineering of various heparin-binding cytokine-delivery systems for biomedical applications and it focuses on our original studies on non-anticoagulant heparin-carrying polystyrene (NAC-HCPS) and polyelectrolyte complex-nano/microparticles (N/MPs), in addition to heparin-coating devices. |
format | Online Article Text |
id | pubmed-6943580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69435802020-01-10 Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers Ishihara, Masayuki Nakamura, Shingo Sato, Yoko Takayama, Tomohiro Fukuda, Koichi Fujita, Masanori Murakami, Kaoru Yokoe, Hidetaka Molecules Review Heparinoid is the generic term that is used for heparin, heparan sulfate (HS), and heparin-like molecules of animal or plant origin and synthetic derivatives of sulfated polysaccharides. Various biological activities of heparin/HS are attributed to their specific interaction and regulation with various heparin-binding cytokines, antithrombin (AT), and extracellular matrix (ECM) biomolecules. Specific domains with distinct saccharide sequences in heparin/HS mediate these interactions are mediated and require different highly sulfated saccharide sequences with different combinations of sulfated groups. Multivalent and cluster effects of the specific sulfated sequences in heparinoids are also important factors that control their interactions and biological activities. This review provides an overview of heparinoid-based biomaterials that offer novel means of engineering of various heparin-binding cytokine-delivery systems for biomedical applications and it focuses on our original studies on non-anticoagulant heparin-carrying polystyrene (NAC-HCPS) and polyelectrolyte complex-nano/microparticles (N/MPs), in addition to heparin-coating devices. MDPI 2019-12-17 /pmc/articles/PMC6943580/ /pubmed/31861225 http://dx.doi.org/10.3390/molecules24244630 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ishihara, Masayuki Nakamura, Shingo Sato, Yoko Takayama, Tomohiro Fukuda, Koichi Fujita, Masanori Murakami, Kaoru Yokoe, Hidetaka Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers |
title | Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers |
title_full | Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers |
title_fullStr | Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers |
title_full_unstemmed | Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers |
title_short | Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers |
title_sort | heparinoid complex-based heparin-binding cytokines and cell delivery carriers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943580/ https://www.ncbi.nlm.nih.gov/pubmed/31861225 http://dx.doi.org/10.3390/molecules24244630 |
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