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Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort

Despite an increasing level of evidence supporting the individual beneficial effect of polyphenols on cognitive performance, information related to the potential synergistic action of these phytonutrients on cognitive performance during a prolonged cognitive effort is currently lacking. This study i...

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Autores principales: Philip, Pierre, Sagaspe, Patricia, Taillard, Jacques, Mandon, Claire, Constans, Joël, Pourtau, Line, Pouchieu, Camille, Angelino, Donato, Mena, Pedro, Martini, Daniela, Del Rio, Daniele, Vauzour, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943592/
https://www.ncbi.nlm.nih.gov/pubmed/31861125
http://dx.doi.org/10.3390/antiox8120650
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author Philip, Pierre
Sagaspe, Patricia
Taillard, Jacques
Mandon, Claire
Constans, Joël
Pourtau, Line
Pouchieu, Camille
Angelino, Donato
Mena, Pedro
Martini, Daniela
Del Rio, Daniele
Vauzour, David
author_facet Philip, Pierre
Sagaspe, Patricia
Taillard, Jacques
Mandon, Claire
Constans, Joël
Pourtau, Line
Pouchieu, Camille
Angelino, Donato
Mena, Pedro
Martini, Daniela
Del Rio, Daniele
Vauzour, David
author_sort Philip, Pierre
collection PubMed
description Despite an increasing level of evidence supporting the individual beneficial effect of polyphenols on cognitive performance, information related to the potential synergistic action of these phytonutrients on cognitive performance during a prolonged cognitive effort is currently lacking. This study investigated the acute and sustained action of a polyphenols-rich extract from grape and blueberry (PEGB), on working memory and attention in healthy students during a prolonged and intensive cognitive effort. In this randomised, cross-over, double blind study, 30 healthy students consumed 600 mg of PEGB or a placebo. Ninety minutes after product intake, cognitive functions were assessed for one hour using a cognitive demand battery including serial subtraction tasks, a rapid visual information processing (RVIP) task and a visual analogical scale. Flow-mediated dilation (FMD) and plasma flavan-3-ols metabolites quantification were also performed. A 2.5-fold increase in serial three subtraction variation net scores was observed following PEGB consumption versus placebo (p < 0.001). A trend towards significance was also observed with RVIP percentage of correct answers (p = 0.058). No treatment effect was observed on FMD. Our findings suggest that consumption of PEGB coupled with a healthy lifestyle may be a safe alternative to acutely improve working memory and attention during a sustained cognitive effort.
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spelling pubmed-69435922020-01-10 Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort Philip, Pierre Sagaspe, Patricia Taillard, Jacques Mandon, Claire Constans, Joël Pourtau, Line Pouchieu, Camille Angelino, Donato Mena, Pedro Martini, Daniela Del Rio, Daniele Vauzour, David Antioxidants (Basel) Article Despite an increasing level of evidence supporting the individual beneficial effect of polyphenols on cognitive performance, information related to the potential synergistic action of these phytonutrients on cognitive performance during a prolonged cognitive effort is currently lacking. This study investigated the acute and sustained action of a polyphenols-rich extract from grape and blueberry (PEGB), on working memory and attention in healthy students during a prolonged and intensive cognitive effort. In this randomised, cross-over, double blind study, 30 healthy students consumed 600 mg of PEGB or a placebo. Ninety minutes after product intake, cognitive functions were assessed for one hour using a cognitive demand battery including serial subtraction tasks, a rapid visual information processing (RVIP) task and a visual analogical scale. Flow-mediated dilation (FMD) and plasma flavan-3-ols metabolites quantification were also performed. A 2.5-fold increase in serial three subtraction variation net scores was observed following PEGB consumption versus placebo (p < 0.001). A trend towards significance was also observed with RVIP percentage of correct answers (p = 0.058). No treatment effect was observed on FMD. Our findings suggest that consumption of PEGB coupled with a healthy lifestyle may be a safe alternative to acutely improve working memory and attention during a sustained cognitive effort. MDPI 2019-12-17 /pmc/articles/PMC6943592/ /pubmed/31861125 http://dx.doi.org/10.3390/antiox8120650 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Philip, Pierre
Sagaspe, Patricia
Taillard, Jacques
Mandon, Claire
Constans, Joël
Pourtau, Line
Pouchieu, Camille
Angelino, Donato
Mena, Pedro
Martini, Daniela
Del Rio, Daniele
Vauzour, David
Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort
title Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort
title_full Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort
title_fullStr Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort
title_full_unstemmed Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort
title_short Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort
title_sort acute intake of a grape and blueberry polyphenol-rich extract ameliorates cognitive performance in healthy young adults during a sustained cognitive effort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943592/
https://www.ncbi.nlm.nih.gov/pubmed/31861125
http://dx.doi.org/10.3390/antiox8120650
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