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Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening
As protein–protein interactions (PPIs) are highly involved in most cellular processes, the discovery of PPI inhibitors that mimic the structure of the natural protein partners is a promising strategy toward the discovery of PPI inhibitors. In this review, we discuss recent advances in the applicatio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943618/ https://www.ncbi.nlm.nih.gov/pubmed/31817099 http://dx.doi.org/10.3390/molecules24244428 |
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author | Wu, Ke-Jia Lei, Pui-Man Liu, Hao Wu, Chun Leung, Chung-Hang Ma, Dik-Lung |
author_facet | Wu, Ke-Jia Lei, Pui-Man Liu, Hao Wu, Chun Leung, Chung-Hang Ma, Dik-Lung |
author_sort | Wu, Ke-Jia |
collection | PubMed |
description | As protein–protein interactions (PPIs) are highly involved in most cellular processes, the discovery of PPI inhibitors that mimic the structure of the natural protein partners is a promising strategy toward the discovery of PPI inhibitors. In this review, we discuss recent advances in the application of virtual screening for identifying mimics of protein partners. The classification and function of the mimicking protein partner inhibitor discovery by virtual screening are described. We anticipate that this review would be of interest to medicinal chemists and chemical biologists working in the field of protein–protein interaction inhibitors or probes. |
format | Online Article Text |
id | pubmed-6943618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69436182020-01-10 Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening Wu, Ke-Jia Lei, Pui-Man Liu, Hao Wu, Chun Leung, Chung-Hang Ma, Dik-Lung Molecules Review As protein–protein interactions (PPIs) are highly involved in most cellular processes, the discovery of PPI inhibitors that mimic the structure of the natural protein partners is a promising strategy toward the discovery of PPI inhibitors. In this review, we discuss recent advances in the application of virtual screening for identifying mimics of protein partners. The classification and function of the mimicking protein partner inhibitor discovery by virtual screening are described. We anticipate that this review would be of interest to medicinal chemists and chemical biologists working in the field of protein–protein interaction inhibitors or probes. MDPI 2019-12-04 /pmc/articles/PMC6943618/ /pubmed/31817099 http://dx.doi.org/10.3390/molecules24244428 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wu, Ke-Jia Lei, Pui-Man Liu, Hao Wu, Chun Leung, Chung-Hang Ma, Dik-Lung Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening |
title | Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening |
title_full | Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening |
title_fullStr | Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening |
title_full_unstemmed | Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening |
title_short | Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening |
title_sort | mimicking strategy for protein–protein interaction inhibitor discovery by virtual screening |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943618/ https://www.ncbi.nlm.nih.gov/pubmed/31817099 http://dx.doi.org/10.3390/molecules24244428 |
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