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Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening

As protein–protein interactions (PPIs) are highly involved in most cellular processes, the discovery of PPI inhibitors that mimic the structure of the natural protein partners is a promising strategy toward the discovery of PPI inhibitors. In this review, we discuss recent advances in the applicatio...

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Detalles Bibliográficos
Autores principales: Wu, Ke-Jia, Lei, Pui-Man, Liu, Hao, Wu, Chun, Leung, Chung-Hang, Ma, Dik-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943618/
https://www.ncbi.nlm.nih.gov/pubmed/31817099
http://dx.doi.org/10.3390/molecules24244428
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author Wu, Ke-Jia
Lei, Pui-Man
Liu, Hao
Wu, Chun
Leung, Chung-Hang
Ma, Dik-Lung
author_facet Wu, Ke-Jia
Lei, Pui-Man
Liu, Hao
Wu, Chun
Leung, Chung-Hang
Ma, Dik-Lung
author_sort Wu, Ke-Jia
collection PubMed
description As protein–protein interactions (PPIs) are highly involved in most cellular processes, the discovery of PPI inhibitors that mimic the structure of the natural protein partners is a promising strategy toward the discovery of PPI inhibitors. In this review, we discuss recent advances in the application of virtual screening for identifying mimics of protein partners. The classification and function of the mimicking protein partner inhibitor discovery by virtual screening are described. We anticipate that this review would be of interest to medicinal chemists and chemical biologists working in the field of protein–protein interaction inhibitors or probes.
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spelling pubmed-69436182020-01-10 Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening Wu, Ke-Jia Lei, Pui-Man Liu, Hao Wu, Chun Leung, Chung-Hang Ma, Dik-Lung Molecules Review As protein–protein interactions (PPIs) are highly involved in most cellular processes, the discovery of PPI inhibitors that mimic the structure of the natural protein partners is a promising strategy toward the discovery of PPI inhibitors. In this review, we discuss recent advances in the application of virtual screening for identifying mimics of protein partners. The classification and function of the mimicking protein partner inhibitor discovery by virtual screening are described. We anticipate that this review would be of interest to medicinal chemists and chemical biologists working in the field of protein–protein interaction inhibitors or probes. MDPI 2019-12-04 /pmc/articles/PMC6943618/ /pubmed/31817099 http://dx.doi.org/10.3390/molecules24244428 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Ke-Jia
Lei, Pui-Man
Liu, Hao
Wu, Chun
Leung, Chung-Hang
Ma, Dik-Lung
Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening
title Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening
title_full Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening
title_fullStr Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening
title_full_unstemmed Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening
title_short Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening
title_sort mimicking strategy for protein–protein interaction inhibitor discovery by virtual screening
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943618/
https://www.ncbi.nlm.nih.gov/pubmed/31817099
http://dx.doi.org/10.3390/molecules24244428
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