Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine

We demonstrate presence of senescent (p16(+), p21(+)) epithelial cells in the stem and transient amplifying cell niches of the intestine in Crohn’s disease. This may explain why Crohn’s lesions recur in the same places.

Detalles Bibliográficos
Autores principales: Wang, Xiaoyan, Bootsma, Hendrika, Kroese, Frans, Dijkstra, Gerard, Pringle, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943680/
https://www.ncbi.nlm.nih.gov/pubmed/31769481
http://dx.doi.org/10.1093/ibd/izz295
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author Wang, Xiaoyan
Bootsma, Hendrika
Kroese, Frans
Dijkstra, Gerard
Pringle, Sarah
author_facet Wang, Xiaoyan
Bootsma, Hendrika
Kroese, Frans
Dijkstra, Gerard
Pringle, Sarah
author_sort Wang, Xiaoyan
collection PubMed
description We demonstrate presence of senescent (p16(+), p21(+)) epithelial cells in the stem and transient amplifying cell niches of the intestine in Crohn’s disease. This may explain why Crohn’s lesions recur in the same places.
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spelling pubmed-69436802020-01-08 Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine Wang, Xiaoyan Bootsma, Hendrika Kroese, Frans Dijkstra, Gerard Pringle, Sarah Inflamm Bowel Dis Letters to the Editor We demonstrate presence of senescent (p16(+), p21(+)) epithelial cells in the stem and transient amplifying cell niches of the intestine in Crohn’s disease. This may explain why Crohn’s lesions recur in the same places. Oxford University Press 2020-02 2019-11-26 /pmc/articles/PMC6943680/ /pubmed/31769481 http://dx.doi.org/10.1093/ibd/izz295 Text en © 2019 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Letters to the Editor
Wang, Xiaoyan
Bootsma, Hendrika
Kroese, Frans
Dijkstra, Gerard
Pringle, Sarah
Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine
title Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine
title_full Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine
title_fullStr Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine
title_full_unstemmed Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine
title_short Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine
title_sort senescent stem and transient amplifying cells in crohn’s disease intestine
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943680/
https://www.ncbi.nlm.nih.gov/pubmed/31769481
http://dx.doi.org/10.1093/ibd/izz295
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