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Immunomodulatory Effects of the Meretrix Meretrix Oligopeptide (QLNWD) on Immune-Deficient Mice

The aim of this study was to explore the immunomodulatory effects of the Meretrix meretrix oligopeptide (MMO, QLNWD) in cyclophosphamide (CTX)-induced immune-deficient mice. Compared to untreated, CTX-induced immune-deficient mice, the spleen and thymus indexes of mice given moderate (100 mg/kg) and...

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Autores principales: Zhang, Wen, Ye, Lei, Wang, Fenglei, Zheng, Jiawen, Tian, Xiaoxiao, Chen, Yan, Ding, Guofang, Yang, Zuisu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943722/
https://www.ncbi.nlm.nih.gov/pubmed/31817348
http://dx.doi.org/10.3390/molecules24244452
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author Zhang, Wen
Ye, Lei
Wang, Fenglei
Zheng, Jiawen
Tian, Xiaoxiao
Chen, Yan
Ding, Guofang
Yang, Zuisu
author_facet Zhang, Wen
Ye, Lei
Wang, Fenglei
Zheng, Jiawen
Tian, Xiaoxiao
Chen, Yan
Ding, Guofang
Yang, Zuisu
author_sort Zhang, Wen
collection PubMed
description The aim of this study was to explore the immunomodulatory effects of the Meretrix meretrix oligopeptide (MMO, QLNWD) in cyclophosphamide (CTX)-induced immune-deficient mice. Compared to untreated, CTX-induced immune-deficient mice, the spleen and thymus indexes of mice given moderate (100 mg/kg) and high (200 mg/kg) doses of MMO were significantly higher (p < 0.05), and body weight loss was alleviated. Hematoxylin-eosin (H&E) staining revealed that MMO reduced spleen injury, thymus injury, and liver injury induced by CTX in mice. Furthermore, MMO boosted the production of immunoglobulin G (IgG) and hemolysin in the serum and promoted the proliferation and differentiation of spleen T-lymphocytes. Taken together, our findings suggest that MMO plays a vital role in protection against immunosuppression in CTX-induced immune-deficient mice and could be a potential immunomodulatory candidate for use in functional foods or immunologic adjuvants.
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spelling pubmed-69437222020-01-10 Immunomodulatory Effects of the Meretrix Meretrix Oligopeptide (QLNWD) on Immune-Deficient Mice Zhang, Wen Ye, Lei Wang, Fenglei Zheng, Jiawen Tian, Xiaoxiao Chen, Yan Ding, Guofang Yang, Zuisu Molecules Article The aim of this study was to explore the immunomodulatory effects of the Meretrix meretrix oligopeptide (MMO, QLNWD) in cyclophosphamide (CTX)-induced immune-deficient mice. Compared to untreated, CTX-induced immune-deficient mice, the spleen and thymus indexes of mice given moderate (100 mg/kg) and high (200 mg/kg) doses of MMO were significantly higher (p < 0.05), and body weight loss was alleviated. Hematoxylin-eosin (H&E) staining revealed that MMO reduced spleen injury, thymus injury, and liver injury induced by CTX in mice. Furthermore, MMO boosted the production of immunoglobulin G (IgG) and hemolysin in the serum and promoted the proliferation and differentiation of spleen T-lymphocytes. Taken together, our findings suggest that MMO plays a vital role in protection against immunosuppression in CTX-induced immune-deficient mice and could be a potential immunomodulatory candidate for use in functional foods or immunologic adjuvants. MDPI 2019-12-05 /pmc/articles/PMC6943722/ /pubmed/31817348 http://dx.doi.org/10.3390/molecules24244452 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Wen
Ye, Lei
Wang, Fenglei
Zheng, Jiawen
Tian, Xiaoxiao
Chen, Yan
Ding, Guofang
Yang, Zuisu
Immunomodulatory Effects of the Meretrix Meretrix Oligopeptide (QLNWD) on Immune-Deficient Mice
title Immunomodulatory Effects of the Meretrix Meretrix Oligopeptide (QLNWD) on Immune-Deficient Mice
title_full Immunomodulatory Effects of the Meretrix Meretrix Oligopeptide (QLNWD) on Immune-Deficient Mice
title_fullStr Immunomodulatory Effects of the Meretrix Meretrix Oligopeptide (QLNWD) on Immune-Deficient Mice
title_full_unstemmed Immunomodulatory Effects of the Meretrix Meretrix Oligopeptide (QLNWD) on Immune-Deficient Mice
title_short Immunomodulatory Effects of the Meretrix Meretrix Oligopeptide (QLNWD) on Immune-Deficient Mice
title_sort immunomodulatory effects of the meretrix meretrix oligopeptide (qlnwd) on immune-deficient mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943722/
https://www.ncbi.nlm.nih.gov/pubmed/31817348
http://dx.doi.org/10.3390/molecules24244452
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